Ischemia-Induced Norepinephrine Release, but not Norepinephrine-Derived Free Radicals, Contributes to Myocardial Ischemia : Reperfusion Injury

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概要

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• Background Norepinephrine (NE)-derived free radicals may contribute to myocyte injury after ischemia-reperfusion, so the influence of sympathetic denervation on myocardial ischemia-reperfusion injury was investigated in the present study. Methods and Results Cardiac sympathetic denervation was produced in Wistar rats by a solution of 10% phenol 1 week before ischemia. Atenolol (0.5mg/kg) was intravenously administered 10 min before the coronary occlusion. The left coronary artery was occluded for 30 min and thereafter reperfused. Cardiac interstitial fluid was collected by a microdialysis probe and free radicals in dialysate were determined by electron paramagnetic resonance (EPR) spin trapping, using 5, 5-dimethyl-l-pyrroline-N-oxide as a spin trap. The ratio of infarct size to the ischemic area at risk (I/R) was decreased in both the phenol and atenolol groups compared with control (28.5±11.3,31.8±10.7 vs 50.6±14.7%, p<0.05). During the coronary occlusion, concentrations of interstitial NE increased markedly in the control and atenolol groups, but was unchanged in the phenol group. EPR signal intensity (relative value to internal standard) was maximal at 1 h after reperfusion and was similar in the phenol and control groups (0.32±0.15 vs 0.45±0.19). Conclusions Cardiac denervation protected myocyte against ischemia-reperfusion injury through decreasing direct NE toxicity, but not through decreasing NE-derived free radicals.

• 社団法人日本循環器学会の論文
• 2005-04-20

著者

• IGARASHI Norio

  Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• FUJII Nozomu

  Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• IGAWA Akihiko

  Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• Inoue Hiroshi

  The Second Department of Internal Medicine, University of Toyama

• Matsuki Akira

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Kondo Takashi

  Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi

• Fujii Nozomu

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Igawa Akihiko

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Igawa Akihiko

  富山医科薬科大学 第2内科

• Igarashi Norio

  富山大学 医学薬学研究部第2内科

• Igarashi Norio

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Inoue Hiroki

  Department Of Chemistry Faculty Of Science Kyushu University

• Nakadate Teruo

  Second Department Of Internal Medicine University Of Toyama

• Nakadate Teruo

  The Second Department of Internal Medicine, University of Toyama

• Matsuki Akira

  The Second Department of Internal Medicine, University of Toyama

• Nozawa Takashi

  The Second Department of Internal Medicine, University of Toyama

• Nonomura Makoto

  The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University

• Igarashi Norio

  The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University

• Fujii Nozomu

  The Second Department of Internal Medicine,Toyama Medical and Pharmaceutical University

• Igawa Akihiko

  The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University

• Asanoi Hidetsugu

  The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University

• Katoh Bunichi

  Imuzu Municipal Hospital

• Matsuki Akira

  Second Department Of Internal Medicine Toyama University Hospital

• Asanoi Hidetsugu

  Imizu Municipal Hospital

• Asanoi Hidetsugu

  The Second Department Of Internal Medicine Toyama Medical & Pharmaceutical University

• Kato Bunichi

  The Second Department of Internal Medicine

• Igawa Akihiko

  The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University

• Igawa Akihiko

  The 2nd Department Of Internal Medicine Toyama Medical And Pharmaceutical University

• Kondo Takashi

  Department Of Diagnostic Radiology Tohoku University School Of Medicine

• Kato Bunichi

  Imuzu municipal hospital

• Nonomura Makoto

  The Second Department Of Internal Medicine University Of Toyama School Of Medicine

• Igarashi Noriko

  The 2nd Department Of Internal Medicine Toyama University

• Inoue Hiroshi

  The Second Department Of Internal Medicine University Of Tokyo

• Asanoi Hidetsugu

  The 2nd Department Of Internal Medicine And Department Of Radiology Toyama Medical And Pharmaceutica

• Asanoi Hidetsugu

  The 2nd Department Of Internal Medicine And Department Of Radiology Toyama Medical And Pharmaceutica

• Kondo Takashi

  Department Of Chemical Engineering Waseda University

• Kondo Takashi

  Department Of Applied Physics Faculty Of Engineering The University Of Tokyo

• Kondo Takashi

  Department Of Radiological Sciences Toyama Medical And Pharmaceutical University

• Inoue Hiroshi

  The Second Department Of Internal Medicine Toyama Medical Phermaceutical University

• Inoue Hiroshi

  The Second Department Of Internal Medicine

• Kondo Takashi

  Department Of Agricultural Chemistry The University Of Tokyo

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