Bradycardia-Dependent ECG Changes in Brugada Syndrome

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概要

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• Background In patients with Brugada syndrome (BS), ventricular fibrillation (VF) occurs mainly during sleep; therefore, not only vagal activity but also bradycardia dependent changes in ECG may relate to the nighttime occurrence of VF. The present study aimed to examine the difference in bradycardia-dependent changes in the ECG of symptomatic and asymptomatic BS patients. Methods and Results Twenty-one patients with BS were categorized into symptomatic (n=9) and asymptomatic (n=12) groups. During the electrophysiologic study, the ECG changes were evaluated at RR intervals of 400, 600, 750, 1,000 and 1,100ms during extrastimulation from the right atrium. The ST levels in V_2, and the QT interval in both V_2 and V_5 were measured. Along with an increase in the RR interval from 400 to 1,100ms, the ST levels in V_2 increased in both groups; the increase did not differ between the 2 groups. In both leads V_2 and V_5, the prolongation of the QT interval along with an increase in the RR interval from 400 to 1,100ms was significantly smaller and the QT intervals at an RR interval of 1,100ms were significantly shorter in the symptomatic than in the asymptomatic group. Conclusions In patients with BS, the ST elevation was augmented during bradycardia to a similar extent in both symptomatic and asymptomatic patients. However, a inhibited prolongation of the QT interval during bradycardia was characteristic of symptomatic patients. These unique repolarization dynamics could relate to the nighttime occurrence ofVF during bradycardia in patients with BS.

• 社団法人日本循環器学会の論文
• 2006-06-20

著者

• Tsuneda Takayuki

  The Second Department of Internal Medicine, University of Toyama

• Inoue Hiroshi

  The Second Department of Internal Medicine, University of Toyama

• Iwamoto Jotaro

  The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Mizumaki Koichi

  Second Department Of Internal Medicine University Of Toyama

• Miwa Kunihisa

  Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University

• Fujiki Akira

  Second Department Of Internal Medicine University Of Toyama

• Inoue Hiroki

  Department Of Chemistry Faculty Of Science Kyushu University

• Fujiki Akira

  The Second Department Of Internal Medicine

• Tsuneda Takayuki

  The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Fujiki Akira

  The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University

• MIZUMAKI Koichi

  The Second Department of Inetranal Medicine, Toyama Medical and Pharmaceutical University

• Sakabe Masao

  The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• Sugao Masataka

  The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• Nishida Kunihiro

  The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• Nagasawa Hidehiko

  The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama

• Miwa Kunihisa

  The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University

• Sakabe Masao

  Second Department Of Internal Medicine University Of Toyama

• Tsutida Takaya

  The First Department Of Internal Medicine Nippon Medical School

• Tanaka Takashi

  The Second Department Of Internal Medicine University Of Toyama

• Nishida Kunihiro

  The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Nagasawa Hidehiko

  The Second Department Of Internal Medicine Faculty Of Medicine University Of Toyama

• Inoue Hiroshi

  The Second Department Of Internal Medicine University Of Tokyo

• Mizumaki Kouichi

  Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers

• Tsuneda Takayuki

  The Cardiovascular Intitule

• Tsuneda Takayuki

  The Second Department Of Internal Medicine University Of Toyama

• Inoue Hiroshi

  The Second Department Of Internal Medicine Toyama Medical Phermaceutical University

• Mizumaki Kohichi

  The Second Department Of Internal Medicine Toyama Medical And Phamaceutical University

• Inoue Hiroshi

  The Second Department Of Internal Medicine

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