Central Sympathetic Inhibition Augments Sleep-Related Ultradian Rhythm of Parasympathetic Tone in Patients With Chronic Heart Failure
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概要
- 論文の詳細を見る
Background Abnormal sleep dynamics in patients with heart failure is one of the mechanisms for the relative predominance of central sympathetic outflow over parasympathetic tone. This study was designed to examine whether central sympathoinhibition could improve the sympathovagal imbalance related to rapid-eye-movement (REM)/non-REM ultradian sleep rhythm in these patients. Methods and Results Beat-by-beat RR intervals of overnight electrocardiogram were serially subject to power spectral analysis in 14 patients with chronic heart failure and 13 age-matched subjects with normal cardiac function. To assess autonomic sleep dynamics, the ultradian rhythm was extracted from all-night consecutive high-frequency (HF) components of heart rate variability (HRV) before and after administration of an α2-adrenergic agonist, guanfacine. Night-time HRV in heart failure was characterized by an attenuated ultradian rhythm of HF-components with a concomitant reduction in averaged HF power. Guanfacine reduced blood pressure, heart rate, and plasma norepinephrine concentrations by 7%, 8%, and 34% (p<0.01), respectively. After guanfacine, HF power rose by 154% (p<0.01) with a prominent augmentation of the all-night ultradian rhythm (+361%, p<0.01). Conclusions Central sympathoinhibition augments a sleep-related ultradian rhythm of parasympathetic tone, suggesting a potential benefit to autonomic balancing and sleep quality in patients with chronic heart failure.
- 社団法人日本循環器学会の論文
- 2005-08-20
著者
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Inoue Hiroshi
The Second Department of Internal Medicine, University of Toyama
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Hirai Tadakazu
Second Department Of Internal Medicine University Of Toyama
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Hirai Tadakazu
The 2nd Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
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Kameyama Tomoki
The Second Department of Internal Medicine, University of Toyama
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Yamazaki Tsugiyoshi
The Second Department of Internal Medicine, University of Toyama
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Nozawa Takashi
The Second Department of Internal Medicine, University of Toyama
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Asanoi Hidetsugu
The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Hirai Tadakazu
University of Toyama
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Ishizaka Shinji
The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Hirai Tadakazu
The Second Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Asanoi Hidetsugu
Imizu Municipal Hospital
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Asanoi Hidetsugu
The Second Department Of Internal Medicine Toyama Medical & Pharmaceutical University
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Yamada Kunihiro
The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Kameyama Tomoki
Second Department of Internal Medicine, University of Toyama
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Ueno Hiroshi
The Second Department of Internal Medicine Toyama Medical & Pharmaceutical University
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Takagawa Junya
The Second Department of Internal Medicine Toyama Medical & Pharmaceutical University
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Ueno Hiroshi
Imizu Municipal Hospital
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Kameyama Tomoki
The Second Department Of Internal Medicine University Of Toyama
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Kameyama Tomoki
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Takagawa Junya
Imizu Municipal Hospital
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Yamada Kunihiro
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Yamazaki Tsugiyoshi
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Ishizaka Shinji
The 2nd Department Of Internal Medicine University Of Toyama
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Hirai Tadakazu
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine University Of Tokyo
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Asanoi Hidetsugu
The 2nd Department Of Internal Medicine And Department Of Radiology Toyama Medical And Pharmaceutica
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Asanoi Hidetsugu
The 2nd Department Of Internal Medicine And Department Of Radiology Toyama Medical And Pharmaceutica
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Inoue Hiroshi
The Second Department Of Internal Medicine Toyama Medical Phermaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine
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