Prolonged Activation of Hemostatic Markers Following Conversion of Atrial Flutter to Sinus Rhythm
スポンサーリンク
概要
- 論文の詳細を見る
Background It remains controversial whether prophylactic anticoagulation for embolism is required in patients with atrial flutter (AFL) prior to and following cardioversion as in patients with atrial fibrillation. To evaluate the potential prothrombotic state following cardioversion of AFL, concentrations of hemostatic markers were determined before and after conversion to sinus rhythm (SR). Methods and Results In 12 patients (mean age 68 years) with AFL who underwent transesophageal echocardiography in the plasma concentrations of markers for platelet activity (platelet factor 4 (PF4) and β-thromboglobulin (β-TG)), thrombotic status (thrombin-antithrombin in complex (TAT) and prothrombin fragments 1 and 2 (F1+2)) and fibrinolytic status (D-dimer and plasmin-α2-plasmin inhibitor complex (PIC)) were determined during AFL, and 3 days and 7 days after restoration of SR. Left atrial appendage (LAA) blood flow velocity was lower immediately after than before restoration of SR (29±11 vs 41±23 cm/s, p<0.05). Three patients developed left atrial spontaneous echo contrast immediately after restoration of SR. Although the concentrations of the markers of platelet activity did not change after restoration of SR, those of TAT and PIC increased 7 days after restoration of SR as compared with during AFL (p<0.05). Conclusions AFL patients have a potential risk for thromboembolism after restoration of SR and therefore anticoagulation might be required in selected patients.
- 社団法人日本循環器学会の論文
- 2004-10-20
著者
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Inoue Hiroshi
The Second Department of Internal Medicine, University of Toyama
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Hirai Tadakazu
Second Department Of Internal Medicine University Of Toyama
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Hirai Tadakazu
The 2nd Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
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Kameyama Tomoki
The Second Department of Internal Medicine, University of Toyama
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Nozawa Takashi
The Second Department of Internal Medicine, University of Toyama
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Asanoi Hidetsugu
The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Hirai Tadakazu
University of Toyama
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Hirai Tadakazu
The Second Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Nakagawa Keiko
The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Nakagawa Keiko
Second Department Internal Medicine, University of Toyama
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Sakurai Kenji
The Second Department of internal Medicine, University of Toyama
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Sakurai Kenji
The Second Department Of Internal Medicine University Of Toyama
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Asanoi Hidetsugu
Imizu Municipal Hospital
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Asanoi Hidetsugu
The Second Department Of Internal Medicine Toyama Medical & Pharmaceutical University
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Kameyama Tomoki
Second Department of Internal Medicine, University of Toyama
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Kameyama Tomoki
The Second Department Of Internal Medicine University Of Toyama
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Kameyama Tomoki
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Nakagawa Keiko
Second Department Internal Medicine University Of Toyama
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Nakagawa Keiko
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Hirai Tadakazu
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine University Of Tokyo
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Asanoi Hidetsugu
The 2nd Department Of Internal Medicine And Department Of Radiology Toyama Medical And Pharmaceutica
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Sakurai Kenji
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Asanoi Hidetsugu
The 2nd Department Of Internal Medicine And Department Of Radiology Toyama Medical And Pharmaceutica
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Inoue Hiroshi
The Second Department Of Internal Medicine Toyama Medical Phermaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine
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