Pharmacological Cardioversion of Persistent Atrial Fibrillation With and Without a History of Drug-Resistant Paroxysmal Atrial Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
Background Suppression by antiarrhythmic drugs of the maintenance mechanisms could convert persistent atrial fibrillation (AF) to sinus rhythm (SR). Whether a history of drug-resistant paroxysmal AF (PAF) would affect the outcome of pharmacological conversion of persistent AF by bepridil or in combination with aprindine was evaluated in the present study. Methods and Results The study group comprised 51 consecutive patients (24 men, 61±8 years) undergoing pharmacological conversion of persistent AF lasting >1 month. Drug-resistant PAF was defined as AF and at least 2 ineffective antiarrhythmic drugs for suppression of AF recurrence. Fast Fourier transform analysis of fibrillation waves was used to measure fibrillation cycle length (FCL) from the peak frequency. Fifteen patients had a history of drug-resistant PAF (Group I), and the remaining 36 did not (Group II) before diagnosis of persistent AF. Ten patients (67%) in Group I and 26 patients (72%) in Group II were restored to SR by bepridil alone or in combination with aprindine after 29±15 days of drug administration. Before conversion to SR, bepridil increased the FCL more in Group II than in Group I. During a 12-month follow-up period, 4 of 10 patients in Group I and 2 of 26 patients in Group II (p<0.01) had recurrence of persistent AF with bepridil alone or in combination with aprindine. Conclusions A history of drug-resistant PAF does not affect the efficacy of pharmacological conversion by bepridil or in combination with aprindine. However, recurrence of AF was significantly higher in patients with such ahistory.
- 社団法人日本循環器学会の論文
- 2006-08-20
著者
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Inoue Hiroshi
The Second Department of Internal Medicine, University of Toyama
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Iwamoto Jotaro
The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Mizumaki Koichi
Second Department Of Internal Medicine University Of Toyama
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Miwa Kunihisa
Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Fujiki Akira
Second Department Of Internal Medicine University Of Toyama
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
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Fujiki Akira
The Second Department Of Internal Medicine
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Fujiki Akira
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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MIZUMAKI Koichi
The Second Department of Inetranal Medicine, Toyama Medical and Pharmaceutical University
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Sakamoto Tamotsu
The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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Nishida Kunihiro
The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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Nagasawa Hidehiko
The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama
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Miwa Kunihisa
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Sakamoto Tamotsu
Second Department Of Internal Medicine University Of Toyama
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Fujiki Akira
Division Of Cardiology Shizuoka Red Cross Hospital
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Nishida Kunihiro
The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Nagasawa Hidehiko
The Second Department Of Internal Medicine Faculty Of Medicine University Of Toyama
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Inoue Hiroshi
The Second Department Of Internal Medicine University Of Tokyo
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Mizumaki Kouichi
Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers
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Inoue Hiroshi
The Second Department Of Internal Medicine Toyama Medical Phermaceutical University
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Mizumaki Kohichi
The Second Department Of Internal Medicine Toyama Medical And Phamaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine
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Fujiki Akira
Department Of Cardiology Japanese Red Cross Shizuoka Hospital
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