Maintenance of Sinus Rhythm and Recovery of Atrial Mechanical Function After Cardioversion With Bepridil or in Combination With Aprindine in Long-Lasting Persistent Atrial Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
Background The aim of this study was to evaluate pharmacological cardioversion of long-lasting persistent atrial fibrillation (AF) using bepridil in terms of recovery of atrial mechanical function and maintenance of sinus rhythm. Bepridil alone or in combination with aprindine is effective for termination of persistent AF. Methods and Results The study group comprised 38 consecutive patients (24 men, 58.8±9.3 years) with successful conversion of persistent AF lasting >1 month either pharmacologically (Group I) or electrically (Group II). Fast Fourier transform analysis of fibrillation waves was performed and fibrillation cycle length (FCL) was calculated from the peak frequency. In Group I, sinus rhythm was pharmacologically restored in 22 patients after an average 30 days (7-49 days) of bepridil administration, either alone (11) or in combination with oral aprindine (11) ; they were followed up while using the same drugs. In Group II, electrical conversion restored sinus rhythm in 16 patients, and they were followed up with conventional antiarrhythmic drugs other than bepridil and aprindine. After bepridil treatment FCL increased and became significantly longer in Group I than in Group II (190±39 vs 150±29ms, p<0.001). Atrial peak velocity in transmitral flow within the first week after cardioversion was greater in Group I than in Group II (68±35 vs 32±20cm/s, p<0.05). By Kaplan-Meier analysis, 83% of Group I patients were free of AF recurrence at the 12-month follow-up, compared with 36% in Group II (p<0.005). Conclusions In patients with long-lasting AF, pharmacological conversion with bepridil alone or in combination with aprindine recovered atrial mechanical function better and maintained sinus rhythm longer than electrical conversion. (Circ J 2004 ; 68 : 834-839)
- 社団法人日本循環器学会の論文
- 2004-08-20
著者
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Tsuneda Takayuki
The Second Department of Internal Medicine, University of Toyama
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Inoue Hiroshi
The Second Department of Internal Medicine, University of Toyama
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Mizumaki Koichi
Second Department Of Internal Medicine University Of Toyama
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Hirai Tadakazu
Second Department Of Internal Medicine University Of Toyama
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Hirai Tadakazu
The 2nd Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Fujiki Akira
Second Department Of Internal Medicine University Of Toyama
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
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Fujiki Akira
The Second Department Of Internal Medicine
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Hirai Tadakazu
University of Toyama
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Hirai Tadakazu
The Second Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Tsuneda Takayuki
The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Nakagawa Keiko
The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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MIZUMAKI Koichi
The Second Department of Inetranal Medicine, Toyama Medical and Pharmaceutical University
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Nakagawa Keiko
Second Department Internal Medicine, University of Toyama
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Sakabe Masao
The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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Miwa Kunihisa
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Sakabe Masao
Second Department Of Internal Medicine University Of Toyama
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Nakagawa Keiko
Second Department Internal Medicine University Of Toyama
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Nakagawa Keiko
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Hirai Tadakazu
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine University Of Tokyo
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Inoue Hiroshi
The Second Department Of Internal Medicine Toyama Medical Phermaceutical University
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Inoue Hiroshi
The Second Department Of Internal Medicine
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