Influence of β-Adrenoceptor Blockade on the Myocardial Accumulation of Fatty Acid Tracer and Its Intracellular Metabolism in the Heart After Ischemia-Reperfusion Injury
スポンサーリンク
概要
- 論文の詳細を見る
Background Increases in sympathetic nerve activity during ischemia may increase intracellular fatty acid (FA) accumulation via enhanced FA uptake and inhibition of β-oxidation. Therefore, the beneficial effects of β-adrenoceptor blockade on myocardial ischemic injury might result from the suppression of FA accumulation. Methods and Results Carvedilol (1mg/kg) or propranolol (1mg/kg) was injected 10min before 15-min occlusion of coronary artery in rats. Myocardial FA accumulation and intracellular metabolites of FA tracer were determined 3 days after reperfusion using ^<125>I- and ^<131>I-9-metylpentadecanoic acid (9MPA). Carvedilol significantly decreased 9MPA accumulation in both the ischemic region (IR) and non-IR, as compared with vehicle, and increased its clearance. However, the non-metabolized 9MPA fraction was not different between carvedilol- and vehicle-treated rats. Consequently, the amount of non-metabolized 9MPA in the myocardium was lower in rats treated with carvedilol than in those given vehicle. These effects of carvedilol were not different from those of propranolol. Conclusion Beta-adrenoceptor blockade did not affect a visual assessment of the autoradiographic image of 9MPA in hearts subjected to ischemia-reperfusion, but it accelerated the clearance of 9MPA in both the IR and non-IR. The administration of β-blockade before ischemia could accelerate the recovery from ischemia-reperfusion injury by inhibiting myocardial FA accumulation before β-oxidation.
- 社団法人日本循環器学会の論文
- 2006-10-20
著者
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MATSUKI Akira
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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NOZAWA Takashi
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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IGARASHI Norio
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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SUZUKI Takayuki
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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FUJII Nozomu
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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IGAWA Akihiko
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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INOUE Hiroshi
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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Nozawa Takashi
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Matsuki Akira
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Fujii Nozomu
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Igawa Akihiko
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Igawa Akihiko
富山医科薬科大学 第2内科
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Igarashi Norio
富山大学 医学薬学研究部第2内科
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Igarashi Norio
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Inoue Hiroshi
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
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Shimizu Takako
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Shimizu T
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Nakadate Teruo
Second Department Of Internal Medicine University Of Toyama
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Shimizu Takako
Graduate School Of Pharmaceutical Sciences University Of Toyama
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Matsuki Akira
Second Department Of Internal Medicine Toyama University Hospital
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Igawa Akihiko
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Igawa Akihiko
The 2nd Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Suzuki Takayuki
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Igarashi Noriko
The 2nd Department Of Internal Medicine Toyama University
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