Nonlinear Mixed Effects Model Analysis of the Pharmacokinetics of Routinely Administered Bepridil in Japanese Patients with Arrhythmias(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
This study was performed to evaluate variability in the pharmacokinetics of bepridil in 38 Japanese patients with arrhythmias, and to investigate the effects of aprindine as well as CYP2D6 and CYP3A5 polymorphisms on the oral clearance of bepridil. We determined the polymorphic alleles of CYP2D6 and CYP3A5 in each subject. The plasma concentration of bepridil at steady-state following repetitive oral administration was measured with an HPLC-based method, and the oral clearance was estimated using the nonlinear mixed effects model (NON-MEM) program. Mean oral clearance was significantly greater in the patients with the CYP2D6^*10 allele than in those without it. On the other hand, no significant effect of the CYP3A5 polymorphism was observed on the pharmacokinetics of bepridil. In addition, aprindine seemed to reduce the oral clearance of bepridil in the patients with the CYP2D6^*10 allele.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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INOUE Hiroshi
Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
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Iwamoto Jotaro
The Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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FUJIKI Akira
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Inoue Hiroshi
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Fujiki Akira
Second Department Of Internal Medicine University Of Toyama
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
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TAGUCHI Masato
Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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HASHIMOTO Yukiya
Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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TAHARA Katsutoshi
Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Iwamoto Jotaro
Second Department of Internal Medicine, Toyama University
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SAIGUSA Katsuya
Graduate School of Pharmaceutical Sciences, University of Toyama
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HORIUCHI Isao
Graduate School of Pharmaceutical Sciences, University of Toyama
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OSHIMA Yukari
Graduate School of Pharmaceutical Sciences, University of Toyama
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Oshima Yukari
Graduate School Of Pharmaceutical Sciences University Of Toyama
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Taguchi Masato
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Hashimoto Yukiya
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Hashimoto Y
Institute Of Molecular & Cellular Biosciences The University Of Tokyo
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Tahara Katsutoshi
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Saigusa Katsuya
Graduate School Of Pharmaceutical Sciences University Of Toyama
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Horiuchi Isao
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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