Different Effects of Temocapril and Cadralazine on Electrocardiographic Voltages and Left Ventricular Mass in Patients with Essential Hypertension.
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概要
- 論文の詳細を見る
To assess whether electrocardiographic variables are useful to detect the regression of left ventricular (LV) mass after long-term antihypertensive treatment, we related electrocardiographic voltages to echocardiographic variables before and after treatment with an ACE inhibitor, temocapril (TEM), or direct vasodilator, cadralazine (CAD). Twenty-one patients with essential hypertension were treated with either TEM (n = 11) or CAD (n = 10) for one year. LV mass index (LVMI) by echocardiography and Sokolow-Lyon voltage (SV<SUB>1</SUB> + RV<SUB>5</SUB>), Cornell voltage (RaV<SUB>L</SUB> + SV<SUB>3</SUB>) and RV<SUB>5</SUB> + RV<SUB>6</SUB> by standard 12-lead electrocardiographic voltages were determined before and after treatment. Both drugs decreased blood pressure to the same extent. Both Sokolow-Lyon voltage and RV<SUB>5</SUB> + RV<SUB>6</SUB> tended to decrease in the ACE group (40.0 ± 9.4 to 37.2 ± 9.4 mm and 44.7 ± 13.5 to 41.7 ± 11.7 mm, respectively, N.S.), but not in the CAD group (38.4 ± 6.8 to 39.7 ± 7.7 mm and 42.9 ± 10.4 to 46.8 ± 11.2 mm, respectively, N.S.). LVMI decreased in the ACE group (-24 ± 22 g/m<SUP>2</SUP>), whereas it increased in the CAD group (37 ±27 g/m<SUP>2</SUP>, p < 0.01). Change in LVMI was correlated with the changes in RV<SUB>5</SUB> + RV<SUB>6</SUB> and Sokolow-Lyon voltage (r = 0.73, p < 0.01 and r = 0.70, p<0.01, respectively), but not with that in Cornell voltage. These results indicated that the changes in voltage criteria of RV<SUB>5</SUB> + RV<SUB>6</SUB> and Sokolow-Lyon are useful to assess the change in LVM after antihypertensive treatment in patients with essential hypertension although voltage variables in electrocardiogram were not sensitive to detect changes in LVMI.
- International Heart Journal刊行会の論文
著者
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Inoue Hiroshi
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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YASUMOTO Kotaro
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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TAKATA Masanobu
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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UENO Hitoshi
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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TOMITA Shin
Second Deparatment of Internal Medicine, Toyama Medical and Pharmaceutical University
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TOMODA Fumihiro
Second Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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YASUMOTO Kotaro
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
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INOUE Hiroshi
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
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UENO Hitoshi
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
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TOMODA Fumihiro
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
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TAKATA Masanobu
Second Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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