Analysis of a cancer stem cell marker EpCAM in an oral squamous cell carcinoma cell line as monolayers and multicellular aggregates

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概要

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• The epithelial cell adhesion molecule (EpCAM) is a Ca^<2+> -independent intracellular adhesion in epithelial tissues, and is highly expressed in several cancers. Despite much research on the function of EpCAM in cancers, complete understanding remains elusive. Recent studies have reported the possibility that EpCAM is a cancer stem cell marker. The expression level of cyclin D1 in monolayer cultures of a human oral squamous cell carcinoma cell line, HSC-4, was not affected by the depression of EpCAM expression using RNA interference (RNAi). On the other hand, suppression of EpCAM reduced the expression level of cyclin D1 in HSC-4 cells as multicellular aggregates (MCAs). Moreover, it was observed that localization of EpCAM protein in HSC-4 cells was altered between MCAs and monolayers. These results suggest that EpCAM regulates the cell growth of HSC-4 through the cyclin D1 expression under anchorage independent conditions. It is proposed that targeting EpCAM might lead to more useful therapies against oral squamous cell carcinoma.

著者

• Nakajima Masahiro

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Sugitatsu Mitsuchika

  Department Of Dentistry And Maxillofacial Surgery Osaka Rad Cross Hospital

• Nakajima Masahiro

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Inoue Hiroshi

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Minamino Yuki

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Kubo Hirohito

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Ohnishi Yuichi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Ugaki Yoshihide

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Fujii Tomoko

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Kakudo Kenji

  Second Department Of Oral And Maxillofacial Surgery Osak Dental University

• Watanabe Masahiro

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental University

• Dateoka Suguru

  Second Department Of Oral And Maxillofacial Surgery Graduate School Of Dentistry Osaka Dental University

• Minamino Yuki

  Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University

• Fujii Tomoko

  Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University

• Ugaki Yoshihide

  Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University

• Sugitatsu Mitsuchika

  Department of Dentistry and Maxillofacial Surgery, Osaka Red Cross Hospital

• Inoue Hiroshi

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University:Department of Dentistry and Maxillofacial Surgery, Osaka Red Cross Hospital

• SUGITATSU Mitsuchika

  Department of Dentistry and Maxiliofacial Surgery, Osaka Red Cross Hospital

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