Early detection of oral precancerous and early cancerous lesions by fluorescence visualization

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概要

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• Early detection of precancerous and early cancerous lesions could greatly reduce both mortality and morbidity of oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of precancerous and early cancerous lesions. Blue excitation light (400 to 460nm) is employed to excite green-red fluorescence from fluorophores in the oral mucosa. Tissue fluorescence is viewed directly along an optical axis collinear with the axis of excitation to reduce interand intraoperator variability. This robust, field-of-view device enables the direct visualization of fluorescence in the context of surrounding normal tissue. Results from a pilot study of 17 patients are presented. In conjunction with histological examinations, this device is extremely useful in detecting oral precancerous and early cancerous lesions. We envisage this device as a suitable adjunct for oral cancer screening and margin determination.

著者

• Kubo Hirohito

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Gotoh Motohiro

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Ohnishi Yuichi

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Nakajima Masahiro

  大阪歯科大学 歯科矯正学講座

• Nakajima Masahiro

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Gotoh Motohiro

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Gotoh Motohiro

  大阪歯科大学 口外2

• Gotoh Motohiro

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Kakudo Kenji

  大阪歯科大学 大学院歯学研究科口腔外科学第二

• Kakudo Kenji

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Morishita Hiroshi

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Inoue Hiroshi

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Goto Michiko

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Minamino Yuki

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Kubo Hirohito

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Dateoka Suguru

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Ohnishi Yuichi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Ugaki Yoshihide

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Kakudo K

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Mori Yui

  Graduate School Of Dentistry (oral And Maxillofacial Surgery) Osaka Dental University

• Kakudo Kenji

  大阪歯科大学 歯学研究科口腔外科学第2

• Sano Yoshiko

  Department Of Orthodontics Osaka Dental University

• Nakajima M

  Osaka Dental Univ. Hirakata‐shi Jpn

• Ohnishi Y

  Osaka Dental Univ. Hirakata‐shi Jpn

• Ohnishi Yuichi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University Hospital

• Morishita Hiroshi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Watanabe Masahiro

  Graduate School of Pharmaceutical Sciences, Tokyo University of Science

• Morishita H

  Graduate School Of Dentistry (oral And Maxillofacial Surgery) Osaka Dental University

• Dateoka Suguru

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Shoju Yuichi

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Kakudo Kenji

  Second Department Of Oral And Maxillofacial Surgery Osak Dental University

• Inoue Hiroshi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Watanabe Masahiro

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental University

• Shoju Yuichi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Dateoka Suguru

  Second Department Of Oral And Maxillofacial Surgery Graduate School Of Dentistry Osaka Dental University

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