Influence of the ratio of α-TCP to autologous bone on bone regeneration in defects around implants
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概要
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α-TCP granules were mixed with crushed autologous bone, and used as a bone substitute in the alveolar bone defect area around implants. We evaluated how the ratio of α-TCP affects treatment. Female Beagle dogs were used as experimental animals. The bilateral mandibular premolars were extracted, and, after osseous healing, a bone defect was created and an implant was placed in the alveolar bone of the tooth extraction site using a trephine bar cooled with saline solution. Crushed autologous bone was used to fill the bone defect area in one group, a mixture of 75% crushed autologous bone and 25% α-TCP (α-tricalcium phosphate) (weight ratio) in another group, a 50% mixture of crushed autologous bone in another group, a 25% mixture in another, and 100% α-TCP in another crushed autologous bone and 25% and filling was performed in one mixture group, and no filling material was placed in the control group. The wound area was closed wound, and the experimental animals were sacrificed 2, 4, and 8 weeks after surgery, and the healing was histologically observed for each group. Undecalcified ground samples were observed with HE staining and Villanueva-Goldner staining to evaluate the amount of bone formation. In the autologous bone group : newly generated bone was confirmed from the second week. The amount of bone continued to increase over time after that. In the α-TCP group the remaining α-TCP granules was observed between 2-4 weeks after surgery, and the invasion of soft tissue was confirmed by the 8th week, almost all the α-TCP granules had been absorbed, and the formation of new bone around the absorption area was confirmed. The α- TCP group showed marked bone formation, in comparison with the control group. The autologous bone group showed clear bone formation, in comparison with the α-TCP group. Furthermore, in the groups where autologous bone and α-TCP were mixed, there was favorable bone formation. The amount of bone formation was dependent on the mixture ratio.
- 2013-04-00
著者
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Haeniwa Hideya
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
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Haeniwa Hideya
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Kakudo Kenji
Second Department Of Oral And Maxillofacial Surgery Osak Dental University
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Kubo Kunitaka
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
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