Age-related changes in glycosaminoglycans of the rat articular condyle
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概要
- 論文の詳細を見る
We performed histochemical and immunohistochemical investigations of changes in glycosaminoglycans(GAG)in the rat mandible at 3, 5, 15, 30 and 50 weeks of age. Mandibular GAG was also extracted for biochemical analysis. We found localization of hyaluronic acid(HA), chondoroitin sulphate(CD), dermatan sulphate(DS)and keratan sulphate(KS)in the articular condyle. Aging reduced the reaction to CD and increased the reaction to DS and KS. There was no clear change in HA in response to aging. Biochemical studies identified HA, CD and KS. CD, which is the main component of total GAG, decreased with age while HA and KS increased. The total amount of GAG in the dry tissue weight, as measured by the volume of uronic acid, decreased with age. These results indicate that the rat articular condyle loses elasticity with age and shows decreased buffering capacity to pressure.
- 大阪歯科学会の論文
著者
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Takahashi Kazuya
Department of Geriatric Dentistry, Osaka Dental University
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Takahashi Kazuya
大阪歯科大学 高齢者歯科学
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Takahashi Kazuya
Department Of Geriatric Dentistry Osaka Dental University
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Murata Yoshinori
Department Of Geriatric Dentistry Osaka Dental University
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Murata Yoshinori
大阪歯科大学 高齢者歯科
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Higuchi Yuichi
Department of Geriatric Dentistry, Osaka Dental University
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Asai Takatsugu
Department of Geriatric Dentistry, Osaka Dental University
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Takahashi Kazuya
Osaka Dental Univ. Osaka Jpn
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Takahashi K
Department Of Geriatric Dentistry Osaka Dental University
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Murata Yoshinori
Department Of Applied Biological Chemistry Faculty Of Agriculture Osaka Prefecture University:(prese
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Higuchi Y
Department Of Geriatric Dentistry Osaka Dental University
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Higuchi Yuichi
Department Of Geriatic Dentistry Osaka Dental University
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Murata Y
Osaka Dental Univ. Osaka Jpn
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Asai T
Department Of Geriatric Dentistry Osaka Dental University
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Asai Takatsugu
Department Of Geriatric Dentistry Osaka Dental University
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Takahashi Kazuya
Department Of Chemistry The University Of Tokyo
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