Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles
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概要
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We evaluated the effects on bone formation of combining synthesized collagen model polypeptides consisting of a Pro-Hyp-Gly [poly(PHG)] sequence and alpha-tricalcium phosphate (α-TCP) particles with various median sizes (large: 580.8 μm; small: 136.2 μm; or large and small mixed: 499.3 μm) in a skull defect model in mini-pigs. Quantitative image analyses for the volume density (VD) of new bone revealed that the VD in each α-TCP group was significantly higher than that in the poly(PHG) control group, with the mixed group showing the highest VD among all the groups at 4 weeks after implantation. Histological assessments revealed that the small α-TCP particles were almost completely degraded at 8 weeks. At 12 weeks, all sizes of α-TCP particles were completely degraded and remodeling of the lamellar bone was observed. The present findings suggest that particle size may influence the success of bone formation in defects.
- 日本歯科理工学会の論文
- 2011-11-01
著者
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Hashimoto Yoshiya
Department Of Biomaterials Osaka Dental University
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Nishiura Aki
Department Of Orthodontics Osaka Dental University
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Matsumoto Naoyuki
Department Of Orthodontics Osaka Dental University
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Baba Shunsuke
Department Of Regenerative Medicine Foundation For Biomedical Research And Innovation
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Baba Shunsuke
Graduate School Of Dentistry Osaka Dental University
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Sakai Kana
Phd Course Graduate School Of Dentistry (orthodontics) Osaka Dental University Department Of Orthodo
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Sakai Kana
Graduate School of Dentistry (Orthodontics), Osaka Dental University
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Sakai Kana
Graduate School Of Dentistry (orthodontics) Osaka Dental University
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Matsumoto Naoyuki
Department Of Biological Safety National Institute For Agro-environmental Sciences
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BABA Shunsuke
Department of Oral Implantology, Osaka Dental University
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Matsumoto Naoyuki
Department and Faculty of Engineering, Graduate School, Chiba Institute of Technology
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