Sub-minimum inhibitory concentration effect of new quinolones on the morphology of the anaerobe gram-negative rods Prevotella and Porphyromonas

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概要

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• We studied the effect of sub-minimum inhibitory concentrations (sub-MIC) of new qui-nolones (NQs) on the morphology of the periodontopathic bacteria Prevotella and Porphyromonas. Six NQs, 6 species of Prevotella (6 strains), 5 species of Porphyromonas (6 strains), Bacteroides fragilis GM 7000 (Bf) and Escherichia coli K 12 (Ec) were used. Cells of all Prevotella species and Porphyromonas asaccharolytica (Pa) elongated 3 to 5 times that of normal cells after anaerobic incubation with sub-MIC NQs. Cells of Porphyromonas, except for Pa, did not elongate under the same conditions. As controls, cells of Bf and Ec with long filaments were observed after the same treatment with NQs. The concentrations of ofloxacin that caused filament formation in Prevotella were 1/64 to 1 MIC, and the range was broader than that in Bf. In levofloxacin-treated Prevotella nigres-ens (Pn) and Ec, a decrease in the number of viable cells was observed before the beginning of filament formation. These results show that the sub-MIC effects of NQs are different on the cell shapes of Prevotella and Porphyromonas. Because all NQs induced short filaments on Prevotella cells and the filament formation started after the reduction of viable cells in levofloxacin-treated Pn, the results from this study also suggest that Pn has a salvage system for escaping the effects of DNA synthesis inhibitors.

• 大阪歯科学会の論文

著者

• Fukushima Hisanori

  Department of Bacteriology, Osaka Dental University

• Fukushima Hisanori

  Department Of Bacteriology Osaka Dental University

• Fukushima Hisanori

  大阪歯科大学 細菌学

• Shirasu Rikiya

  First Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Shirasu Rikiya

  First Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Matsumoto Kazuhiro

  First Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Onoe Takatoshi

  Department Of Bacteriology Osaka Dental University

• Shimatani Hiroyuki

  Graduate School of Dentistny (Bacteriology), Osaka Dental University

• Maeda Takeo

  First Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Murata Yuichi

  First Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Sagawa Hirosuke

  Department of Bacteriology, Osaka Dental University

• Shimatani Hiroyuki

  Graduate School Of Dentistny (bacteriology) Osaka Dental University

• Maeda Takeo

  First Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Murata Yuichi

  First Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Matsumoto Kazuhiro

  First Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Matsumoto Kazuhiro

  Osaka Dental Univ. Osaka Jpn

• Sagawa Hirosuke

  Department Of Bacteriology Osaka Dental University

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