Effectiveness of calcium hydroxide on LPS-induced hard tissue resorption

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概要

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• Although the application of calcium hydroxide in the root canal is reportedly effective for the prevention of external root resorption, details of its mechanism of action are unclear. We studied the effect of calcium hydroxide on the expression of Iipopolysaccharide (LPS) induced hard tissue resorption-related genes in human osteoblastic cells (Saos-2) to evaluate how it prevented hard tissue resorption. The effects of calcium hydroxide on the expression of genes of TNF-α, IL-6, OPG and RANKL expressed by LPS-stimulated human osteoblastic cells were evaluated using the real-time reverse transcriptase-polymerase chain reaction. The data were compared employing Student's t-test (n=6) at the significance level of 0.05. Calcium hydroxide inhibited the expression of proinflammatory cytokines induced by LPS. It also inhibited the expression of RANKL, which is always expressed in human osteoblastic cells. Calcium hydroxide appeared to inhibit LPS-induced inflammatory hard tissue resorption.

著者

• Baba Tadahiko

  Department of Endodontics Osaka Dental University

• Hayashi Hiroyuki

  Department of Endodontics, Osaka Dental University

• Shida Muneyasu

  Department of Endodontics, Osaka Dental University

• Taguchi Yoichiro

  Department of Periodontology, Osaka Dental University

• Ueda Masatoshi

  Department of Periodontology, Osaka Dental University

• Ueda Masatoshi

  大阪歯科大学 細菌学

• Ueda Masatoshi

  Department Of Periodontology Osaka Dental University

• Ueda Masatoshi

  大阪歯科大学 歯研究 薬理

• Kon'i Hirotaka

  大阪歯科大学 欠損歯列補綴咬合学

• Kon'i Hirotaka

  Department Of Postgraduate Clinical Training Osaka Dental University

• Ueda Masatoshi

  Osaka Dental Univ. Osaka Jpn

• Ueda Mika

  Department Of Periodontology Osaka Dental University

• Shida Muneyasu

  Department Of Endodontics Osaka Dental University

• Hayashi Hiroyuki

  Osaka Dental Univ. Osaka Jpn

• Taguchi Yoichiro

  Department Of Periodontology Osaka Dental University

• Hayashi Hiroyuki

  Department Of Endodontics Osaka Dental University

• Hayashi Hiroyuki

  Department Of Cardiology Kanazawa Medical University

• Hayashi Hiroyuki

  Department Of Applied Chemistry Faculty Of Engineering Osaka Institute Of Technology

• HAYASHI Hiroyuki

  Department of Advanced Energy, University of Tokyo, Kashiwa, Chiba 277-8561, Japan

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