Induction of osteoprotegerin mRNA during differentiation of monocytes into macrophages
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the mRNA expression of osteoprotegerin, receptor activator of nuclear factor-_κB (RANK) and RANK ligand (RANKL) in human leukemia cell lines. When the cells took on a macrophage-like morphology after treatment with a phorbol ester, mRNA for osteoprotegerin was clearly induced. In contrast, RANK or RANKL mRNA expression did not change significantly. Considering that monocytic leukocytes are often found in periodontitis and osteoprotegerin inhibits maturation of osteoclast precursor cells into osteoclasts, our data suggest that differentiation of monocytes into macrophages in periodontitis may prevent local osteoclastogenesis. This could be a defensive mechanism against bone resorption during the course of periodontitis.
- 大阪歯科学会の論文
著者
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Domae Naochika
Department of Internal Medicine, Osaka Dental University
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Ueda Masatoshi
Department of Periodontology, Osaka Dental University
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Ueda Masatoshi
Department Of Periodontology Osaka Dental University
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Domae Naochika
Osaka Dental Univ. Osaka Jpn
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Domae Naochika
Department Of Internal Medicine Osaka Dental University
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NAGANO Yutaka
Department of Medicine, Osaka Dental University
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Notohara Yasuhiro
Graduate School of Dentistry (Periodontology), Osaka Dental University
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Nagano Yutaka
Department Of Internal Medicine 3rd Division Faculty Of Medicine Kyoto University
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Nagano Yutaka
Department Of Internal Medicine Osaka Dental University
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Notohara Yasuhiro
Graduate School Of Dentistry (periodontology) Osaka Dental University
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NAGANO YUTAKA
Department of Internal Medicine, Osaka Dental University
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