Matrix metalloproteinase 1 produced by CXCL12 stimulation on NK92 cells

概要

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Natural killer (NK) cells play a key role in inflammation and tumor regression through their ability to migrate into tissues. The two major subsets in NK cells are CD56^<bright> CD16^<dim/-> and CD56^<dim> CD16^+. The cytotoxic activity of CD56^<dim> NK cells is significantly greater than that of CD56^<bright> cells. Regarding cytokine production, the situation is inverted. CD56^<bright> NK cells are the most efficient cytokine producers. The role of CD56^<bright> CD16^- cells is not clear. CXCL12 is a chemokine that promotes Iymphocyte invasion and migration into tissues; however, the mechanism for this process remains incompletely understood. This study demonstrated that the NK92 cell population, which is the human NK cell line, was CD56^<bright> CD16^-. We examined the production of pro-matrix metalloproteinase (MMP) 1 induced by CXCL12 stimulation on NK92 cells. Pro-MMP 1 production was significantly enhanced by CXCL12 stimulation. In addition, the production of pro-MMP 1 was markedly inhibited by SB203580 (p38 inhibitor). These results suggest that p38, which is the family of mitogen activated protein kinases (MAPKs), was involved in the production of pro-MMP 1 from CXCL12-stimulated CD56^<bright> CD16^- NK92 cells.
大阪歯科学会の論文