Effects of Allopurinol on Tissue Oxygen Tension of the Ischemic Myocardium
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概要
- 論文の詳細を見る
The effects of allopurinol on the myocardial oxygen metabolism were studied in dogs with acute coronary artery occlusion. Upon occlusion of the contributory branch of the coronary artery, myocardial pO2, as measured with an improved polarographic technique, decreased to various lower values depending on the site of the electrode inserted. In the slightly ischemic myocardium, where myocardial pO2 decreased less than 50% of the control by the coronary occlusion, administration of allopurinol brought about a further diminution in myocardial pO2. In the severely ischemic myocardium, where myocardial pO2 decreased more than 50% of the control upon the coronary occlusion, no significant change was observed following allopurinol infusion. Theoretical beneficial effects of allopurinol on the ischemic myocardium by preserving functional purine bases might be offset by the aggravation of the negative oxygen balance in the ischemic but still viable myocardium following administration of allopurinol.
- International Heart Journal刊行会の論文
著者
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MIZUNO Akira
Department of Astrophysics, Nagoya University
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Furuse Akira
Department of Cardiovascular Surgery, Toranomon Hospital
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INOUE Hiroshi
Department of Internal Medicine, University of Toyama
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Furuse Akira
Department Of Thoracic Surgery And The Second Department Of Medicine University Of Tokyo
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Furuse Aklra
Dept. Of Thoracic Surg. Univ. Of Tokyo
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Furuse Akira
Dept. Of Surg. (prof. S. Kimoto) And Dept. Of Thoracic Surg. Facul. Of Med. University Of Tokyo Toky
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Furuse Akira
Department Of Cardiothoracic Surgery University Of Tokyo
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Saigusa Masahiro
Department of Thoracic Surgery, University of Tokyo
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Saigusa Masahiro
Department Of Thoracic Surgery And The Second Department Of Medicine University Of Tokyo
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Inoue Hiroshi
Department Of Electrical And Electronic Engineering Akita University
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Mizuno Akira
Department Of Astrophysics Nagoya University
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Inoue Hiroshi
Departmcnt Of Biology Faculty Of Science Kyushu University:(present)department Of Biology Kyushu Den
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MIZUNO Akira
Department of Thoracic Surgery, University of Tokyo
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SAIGUSA Masahiro
Department of Thoracic Surgery and the Department of Gynecology and Obstetrics, University of Tokyo
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FURUSE Akira
Department of Thoracic Surgery, University of Tokyo
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INOUE Hiroshi
Department of Thoracic Surgery, University of Tokyo
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Inoue Hiroshi
Deparment of Neurosurgery, Gunma University School of Medicine and Gamma Unit Center, Hidaka Hospital
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FURUSE Akira
Department of Cardiothoracic Surgery and the Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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SAIGUSA Masahiro
Department of Surgery, Faculty of Medicine, University of Tokyo
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