Mixed Pituitary Adenoma and Gangliocytoma Associated with Acromegaly : Case Report
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概要
- 論文の詳細を見る
A gangliocytoma in the sellar region is very rare. We report a case of an intrasellar gangliocytoma complicated by pituitary adenoma presenting with acromegaly. A 52-year-old female was admitted to our hospital with headache, mild acromegaly, and bitemporal hemianopsia, and endocrinological study found a high serum level of growth hormone (GH). A computed tomographic scan revealed a tumor in the sellar region, which was almost totally removed by trans-sphenoidal surgery. Histological examination of the resected specimen showed diffuse, chromophobe-type pituitary adenoma, partially containing cholesterin clefts. Areas of clusters of dysmorphic neurons, adjacent to or mixed with pituitary adenoma, were diagnosed as gangliocytoma. The immunohistochemical examination showed GH-releasing hormone (GRH)-positive dysmorphic neurons and GH-positive pituitary adenoma. We consider that the trophic effect of GRH secreted by the neurons of GRH-producing intrasellar gangliocytoma probably caused the GH-producing pituitary adenoma.
- 日本脳神経外科学会の論文
- 1990-08-15
著者
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ASADA Hideo
Department of Dermatology, Nara Medical University
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INOUE Hiroshi
Department of Internal Medicine, University of Toyama
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Toya Shigeo
Department Of Neurosurgery Keio University School Of Medicine
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Toya Shigeo
Department Of Neurological Surgery Keio University
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Asada Hideo
Department Of Dermatology Nara Medical University
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Asada Hideo
Department Of Neurosurgery School Of Medicine Keio University
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Toya S
Keio Univ. Tokyo Jpn
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OGAWA Yoshihiro
Department of Radiation Oncology, Tohoku University, Graduate School of Medicine
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Otani Mitsuhiro
Department of Pathology, Kitasato University
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FURUHATA Shigeru
Department of Neurosurgery, Keio University School of Medicine
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Ogawa Yoshihiro
Department Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Furuhata Shigeru
Department Of Neurosurgery Keio University School Of Medicine
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Otani Mitsuhiro
Department Of Neurosurgery Keio University School Of Medicine
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Inoue Hiroshi
Department Of Electrical And Electronic Engineering Akita University
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Inoue H
Department Of Removable Prosthodontics And Occlusion Osaka Dental University
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Ogawa Yoshihiro
Department Of Neuropathology Tokyo Metropolitan Institute For Neuroscience
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Inoue Hiroshi
Departmcnt Of Biology Faculty Of Science Kyushu University:(present)department Of Biology Kyushu Den
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Inoue Hiroshi
Deparment of Neurosurgery, Gunma University School of Medicine and Gamma Unit Center, Hidaka Hospital
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