DISTRIBUTION AND PROGRESSION OF CORONARY ARTERIAL AND AORTIC LESIONS IN THE CONVENTIONAL WATANABE HERITABLE HYPERLIPIDEMIC RABBIT : Quantitative Analysis

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概要

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• The distribution and progression of coronary arterial and aortic lesions were examined in 40 conventional Watanabe Heritable Hyperlipidemic (WHHL) rabbits. They were classified according to age into stage I (3-5 months old, 14 rabbits), stage II (6-12 months old; 12 rabbits) and stage III (14-28 months old; 14 rabbits). Fifteen normal Japanese rabbits served as controls. The findings obtained from serial and trasverse sections of each of the extramural coronary arteries (ECA) and trasverse section of each of 4 to 5 equal pieces of whole ventricle for intramural coronary arteries (ICA) were quantified by an image analyzer. Atherosclerosis with positive Sudan III stain was seen in aorta, ECA and ICA over 200μ in diameter. Atherosclerotic lesions were noted in the aortic arch in stage I rabbits and in the whole aorta in stages II and III rabbits. In ECA, stenosis due to atherosclerosis was noted in 14, 33 and 93% of stages I, II and III rabbits, respectively. Stenosis of over 75% in the orifices of the left and right coronary arteries was noted frequently (71%), while mural thrombi, hemorrhage, intimal rupture and recanalization were seen rarely. Striking features were non-atherosclerotic stenosis with negative Sudan III, seen in the ICA less than 200 in diameter of almost all the hearts of stages II and III rabbits. Acute and old myocardial infarction appeared in 5 of the 14 hearts of the stage III rabbits and the infarct-related ECA showed severe stenosis of over 90%. In conclusion, to detect coronary atherosclerosis, serial and transverse sections of ECA are needed. In conventional WHHL rabbits, the incidence of stenosis in ECA is very high, compared with that of the previous reports, and myocardial infarction is due to severe stenosis in ECA. Non-atherosclerotic lesions in ICA occur before the appearance of the atherosclerotic lesions in ECA.

• 社団法人日本循環器学会の論文
• 1988-04-20

著者

• FUJIWARA TAKAKO

  Department of Pediatrics, Faculty of Medicine, Kyoto University

• Fujiwara Takako

  Department Of Food Science Kyoto Women's University

• Takahashi Masaaki

  The Third Division Department Of Internal Medicine Kyoto University

• Wu Der-jinn

  Chung Shang Medical University Hospital

• Matsuda Mitsuhiko

  Department Of Internal Medicine Yamaguchi University

• Hamashima Yoshihiro

  Department Of Biomaterials Institute For Frontier Medical Sciences Kyoto University

• FUJIWARA HISAYOSHI

  The Third Division,Department of Internal Medicine, Faculty of Medicine, Kyoto University

• Kawamura Atsushi

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Tanaka M

  Osaka City Univ. Medical School

• Tanaka Masahiro

  Rakuwakai Otowa Hospital

• Yokoyama Haruko

  Department Of Biomaterials Institute For Frontier Medical Sciences Kyoto University

• Kawai Chuichi

  The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University

• Matsuda Mitsuo

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Onodera Tomoya

  Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un

• Ishii Kenji

  Department Of Geriatric Medicine Kyoto University Faculty Of Medicine

• Kawamura Atsushi

  Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University

• Tanaka Masaru

  The Third Division of Medicine, Kyoto University

• ISHIDA MORIHARU

  Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University

• ISHIDA Moriharu

  The Third Division,Faculty of Medicine,Kyoto University

• TAKEMURA Genzou

  The Third Division,Faculty of Medicine,Kyoto University

• WU DER-JINN

  The Third Division, Department of Internal Medicine ,Kyoto University

• ONODERA TOMOYA

  The Third Division, Department of Internal Medicine ,Kyoto University

• NAGANO YUTAKA

  The Third Division, Department of Internal Medicine ,Kyoto University

• ISHII KENJI

  The Third Division, Department of Internal Medicine ,Kyoto University

• KITA TORU

  The Third Division, Department of Internal Medicine ,Kyoto University

• Matsuda Mitsuo

  Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University

• Kita Toru

  The Third Devision Department Of Internal Medicine Kyoto University

• Kita Toru

  Department Of Clinical Bio-regulatory Science Division Of Molecular Medicine For Adult And Geriatric

• Fujiwara Hisayoshi

  The Third Division Of Internal Medicine Kyoto University

• Kawai Chuichi

  The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Nagano Yutaka

  Department Of Internal Medicine 3rd Division Faculty Of Medicine Kyoto University

• Wu Der-jinn

  The Third Division Departments Of Internal Medicine

• Himura Yoshihiro

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Ishida Moriharu

  Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University

• Hayakawa Yukihiro

  Department Of Biomaterials Institute For Frontier Medical Sciences Kyoto University

• Yokoyama Haruko

  Regeneration & Advanced Medical Science

• Motai Michio

  Section Of Technology Heiwa-bussan Co. Ltd.

• Takashima Masayuki

  Third Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Tanaka Masaru

  Department Of Cardiology Cardiovascular Center Osaka Red Cross Hospital

• Tanaka Masaru

  The Third Division Of Medicine Kyoto University

• Tanaka Makoto

  Cardiovascular Center Osaka Red Cross Hospital

• Fujiwara Hisayoshi

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University Kyoto

• Yokoyama Haruko

  Regeneration & Advanced Medical Science Graduate School Of Medicine Gifu University

• Matsuda Mitsuo

  Department Of Internal Medicine Yamaguchi University

• Onodera Tomoya

  Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un

• Ishida Moriharu

  Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un

• Kawamura Atsusi

  Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un

• Kawamura Atsusi

  Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un

• Ishida Moriharu

  Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un

• Tanaka Masaru

  Third Division Department Of Internal Medicine Kyoto University

• Takashima Masayuki

  Cardiovascular Center Osaka Red Cross Hospital

• Ishida Moriharu

  Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto University

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