Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits
スポンサーリンク
概要
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Background Statins reportedly protect against myocardial infarction, but the precise mechanism is unclear. Methods and Results Rabbits underwent 30 min of coronary occlusion followed by 48h of reperfusion. Pravastatin (1 or 5mg/kg) or saline was intravenously administered 10 min before ischemia. Pravastatin (5mg/kg) was also administered 10 min before reperfusion. N^<ω>-nitro-L-arginine methylester (L-NAME, 10mg/kg), chelerythrine (5mg/kg) or 5-hydroxydecanoic acid sodium salt (5-HD, 5mg/kg) was intravenously administered 10 min before pravastatin injection. The infarct size was determined. The myocardial interstitial levels of 2, 5-dihydroxybenzoic acid (DHBA) and nitrogen oxide (NOx), and the intensity of myocardial dihydroethidium staining were measured. Pre-ischemic treatment with pravastatin reduced the infarct size (34±5% and 24±4%, 1 and 5mg/kg, respectively), but not pre-reperfusion treatment (42.1±3.7%), compared with the control (45±3%). This effect was blocked by L-NAME (42.6±4%), chelerythrine (50.9±3%) and 5-HD (52.7±2%). Pre-ischemic treatment with pravastatin increased myocardial NOx levels, and attenuated both the 2, 5-DHBA level and the intensity of dihydroethidium staining during reperfusion. Chelerythrine abolished the increase in NOx levels by pravastatin. Conclusion Pre-ischemic treatment with pravastatin reduces the myocardial infarct size via protein kinase C-dependent nitric oxide production, decreasing hydroxyl radicals and superoxide, and opening the mitochondrial adenosine triphosphate-sensitive potassium channels.
- 社団法人日本循環器学会の論文
- 2007-09-20
著者
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藤原 久義
岐阜大学第二内科
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藤原 久義
兵庫県立尼崎病院 循環器内科
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Yamaki Takahiko
Department Of Cardiology Gifu University Graduate School Of Medicine
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BAO Narentuoya
Department of Cardiology, Gifu University Graduate School of Medicine
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KAWAMURA Itta
Department of Cardiology, Gifu University Graduate School of Medicine
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NISHIGAKI Kazuhiko
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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YASUDA Shinji
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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YAMAKI Takahiko
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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MINATOGUCHI Shinya
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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KAWAMURA Itta
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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TAKEMURA Genzou
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
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FUJIWARA Hisayoshi
Second Department of Internal Medicine, Gifu University School of Medicine
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Takemura Genzou
岐阜大学 医学系研究科循環病態学
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Takemura Genzou
岐阜大学 医学部第二内科
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Nishigaki Kazuhiko
岐阜大学 医学系研究科循環病態学
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Nishigaki Kazuhiro
Department Of Cardiology Gifu University Graduate School Of Medicine
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Iwasa Masamitsu
Department Of Cardiology Gifu University Graduate School Of Medicine
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Yamashita Shuji
Department Of Cardiology Gifu University Graduate School Of Medicine
-
Sumi Shohei
Department Of Cardiology Gifu University Graduate School Of Medicine
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Fujiwara Takako
Kyoto Women's University
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Bao Narentuoya
Second Department of Internal Medicine, Gifu University School of Medicine
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Kobayashi Hiroyuki
Second Department of Internal Medicine, Gifu University School of Medicine
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Iwasa Masamitsu
Second Department of Internal Medicine, Gifu University School of Medicine
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Sumi Syohei
Second Department of Internal Medicine, Gifu University School of Medicine
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Misao Yu
Second Department of Internal Medicine, Gifu University School of Medicine
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Arai Masazumi
Second Department of Internal Medicine, Gifu University School of Medicine
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Kawamura Itta
Department Of Cardiology Gifu University Graduate School Of Medicine
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Bao Narentuoya
Department Of Cardiology Gifu University Graduate School Of Medicine
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Fujiwara Takako
Department Of Food Science Kyoto Women's University
-
Misao Yu
Department Of Cardiology Gifu University Graduate School Of Medicine
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Tabata Y
Department Of Cardiology Gifu University Graduate School Of Medicine
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Matsumori Akira
岡山大学 循環器内科
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Marui A
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Two Ya
Department Of Cardiology Gifu University Graduate School Of Medicine
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藤原 久義
岐阜大学 大学院医学研究科東洋医学講座
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Yasuda Shinji
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
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Takemura Genzo
Kyoto Women's University And Department Of Internal Medicine Kyoto University
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Matsumori Akira
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Kobayashi Hiroyuki
Department Of Cardiology Gifu University Graduate School Of Medicine
-
Fujiwara Takako
Kyoto Women's University
-
Fujiwara Hisayoshi
The Third Division Of Medicine Kyoto University
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Fujiwara Hisayoshi
Department Of Regenerative And Advanced Medical Science Gifu University Graduate School Of Medicine
-
Minatoguchi Shinya
Second Department Of Medicine Gifu University Graduate School Of Medicine
-
Fujiwara Hisayoshi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Matsumori Akira
The Third Devision Department Of Internal Medicine Kyoto University
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KAWASAKI Hironobu
Ibi Kosei Hospital
-
Fujiwara Hisayoshi
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
-
Fujiwara Takako
Pediatrics
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Fujiwara Takako
Department Of Pediatrics Faculty Of Medicine Kyoto University
-
Minatoguchi Shinya
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
-
Arai Masazumi
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
-
Matsumori Akira
Department Of Cardiology Kyoto University
-
Nishigaki Kazuhiko
Second Department Of Internal Medicine Gifu University
-
Fujiwara Takako
Department Of Food Science Kyoto Women's University And The Third Division Department Of Intern
-
Fujiwara Hisayoshi
Second Department Of Internal Medicine Faeulty Of Medicine Gifu University
-
Yamaki Takahiko
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
-
Marui Akira
Division Of Cardiology Kyoto Medical Center National Hospital Organization
-
Matsumori Akira
Department Of Cardiovascular Medicne Kyoto University Graduate School Of Medicine
-
Takemura Genzou
Second Dep. Of Internal Medicine Graduate School Of Medicine Gifu Univ.
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Yamaki Takahiko
Department of Cardiology, Gifu University Graduate School of Medicine
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