Infarct Size and the Protection of Ischemic Myocardium in Pig, Dog and Human : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research
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概要
- 論文の詳細を見る
To define whether recanalization after occlusion can reduce the myocardial infarct size, we compared the infarct size in 25 pig hearts without collateral circulation, 35 dog hearts with collateral circulation and 11 human autopsied hearts with coronary thrombolysis at 2 to 6 hours after the onset of acute myocardial infarction. The data showed that % infarct size in the risk area increased according to the duration of occlusion. In the pig, % infarct size was 80±9% in the recanalization after 1 hour occlusion and 96±2% in the recanalization and the permanent occlusion group (95±3%). In the dog, % infarct size was 35±31% in the recanalization after 4 hour occlusion and 59±27% in the permanent occlusion group. In human autopsied hearts, the infarct size was was the same between the recanalization group (82±6%) and the permanent occlusion group (80±11%). The % infarct size in the recanalization groups was less than or the same as that in the hearts with permanent occlusion in dog, pig and human. Thus, it is concluded that, to reduce conclusively the infarct size, recanalization should be done within 1 hour after the occlusion in the hearts without collateral circulation and within 4 hours in the hearts with collateral circulation. So called reperfusion injury which means the greater expansion of the % infarct size than that in the permanent occlusion is not present.
- 社団法人日本循環器学会の論文
- 1989-09-20
著者
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FUJIWARA TAKAKO
Department of Pediatrics, Faculty of Medicine, Kyoto University
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Kawamura Atsushi
Department of Cardiovascular Medicine, National Cardiovascular Center
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TAKEMURA Genzou
Department of Cardiology, Gifu University Graduate School of Medicine
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Fujiwara Hisayoshi
Department of Cardiology, Gifu University School of Medicine
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Takemura Genzou
Department Of Cardiology Gifu University Graduate School Of Medicine
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Fujiwara Hisayoshi
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Fujiwara Takako
Department Of Food Science Kyoto Women's University
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Takahashi Masaaki
The Third Division Department Of Internal Medicine Kyoto University
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Kida Mitsugu
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Matsuda Mitsuhiko
Department Of Internal Medicine Yamaguchi University
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Matsuda Mitsuo
Department of Internal Medicine, The University of Tsukuba
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Tanaka Masahiro
Department of Fixed Prosthodontics and Occlusion, Osaka Dental University
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Tanaka M
Osaka City Univ. Medical School
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Tanaka Masahiro
Rakuwakai Otowa Hospital
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Kawai Chuichi
Department of Cardiology, Takeda General Hospital
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Ueda Tadashi
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Ueda Tadashi
Department Of Pediatrics Mitsubishi Kyoto Hospital
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Uegaito Takashi
Department of Cardiology, Kishiwada City Hospital
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Tanaka Masahiro
Department Of Applied Chemistry
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Kawai Chuichi
Department Of 3rd Internal Medicine Faculty Of Medicine Kyoto University
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Matsuda Mitsuo
Department Of Cardiology Kishiwada City Hospital
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Matsuda Mitsuo
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kawamura Atsushi
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Ishida Moriharu
Department of Cardiovascular Surgery, and The Third Division, Department of Internal Medicine, Kyoto
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KIDA Mitsugu
The Third Division of Internal Medicine,Kyoto University
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HORIE KIYOSHI
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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ISHIDA MORIHARU
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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FUJIWARA YASUNORI
Kyoto Women's University
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HORIKE KIYOSHI
Department of Cardiovascular Surgery, Faculty of Medicine, Kyoto University
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Fujiwara Yasunori
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Matsuda Mitsuo
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Kida Mitsugu
The Third Division Of Internal Medicine Kyoto University
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Horie Kiyoshi
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Ishida Moriharu
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Uegaito Takashi
Department Of Cardiology Kishiwada City Hospital
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Motai Michio
Section Of Technology Heiwa-bussan Co. Ltd.
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Fujiwara Yasunori
Kyoto Women's University
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Matsuda Mitsuhiko
Kokura Memorial Hospital Cardiovascular Surgery
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Uegaito Takashi
The Third Division Faculty Of Medicine Kyoto University
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Takashima Masayuki
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Tanaka Masaru
Department Of Cardiology Cardiovascular Center Osaka Red Cross Hospital
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Tanaka Makoto
Cardiovascular Center Osaka Red Cross Hospital
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Matsuda Mitsuo
Department Of Internal Medicine Yamaguchi University
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Ishida Moriharu
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Kawamura Atsusi
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Kawamura Atsusi
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Ishida Moriharu
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Tanaka Masaru
Third Division Department Of Internal Medicine Kyoto University
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Tanaka Masahiro
Department Fixed Prosthodontics And Occlusion Osaka Dental University
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Takashima Masayuki
Cardiovascular Center Osaka Red Cross Hospital
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Ishida Moriharu
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto University
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