Nuclear Hypertrophy Reflects Increased Biosynthetic Activities in Myocytes of Human Hypertrophic Hearts(Clinical Investigation)

スポンサーリンク

概要

• 論文の詳細を見る

• Background The nucleus of the myocytes in human hypertrophic hearts is characterized by its bizarre shape and widespread clumping of chromatin. The functional significance has not been determined. Methods and Results Left ventricular (LV) endomyocardial biopsies obtained from patients with dilated cardiomyopathy (DCM, n=23), postmyocarditis (n=13), hypertrophic cardiomyopathy (HCM, n=21), apical hypertrophic cardiomyopathy (APH, n=11) and hypertensive heart disease (HHD, n=11), and from nonhypertrophic hearts (controls, n=14) were examined. Myocyte size and LV mass index were similar among the hypertrophic hearts, but the nuclear hypertrophy score (grade 0-3) was highest in hearts with systolic failure (DCM and postmyocarditis) and higher in those without it (HCM, APH, and HHD), compared with controls. So were biosynthetic activities such as DNA repair/synthesis, immunohistochemically assessed by proliferating cell nuclear antigen, transcription activity by spliceosome component of 35kDa, and translation efficiency by 70kDa S6 protein kinase. There were significant correlations between nuclear hypertrophy and each biosynthetic activity. Additionally, most of the proliferating cell nuclear antigen-positive nuclei co-expressed oxidative DNA damage markers. Conclusion A link is suggested between structural alteration and molecular biological events in the nuclei of myocytes from human hypertrophic hearts; the nuclear hypertrophy reflects increased biosynthetic activities of DNA repair/synthesis, transcription, and translation efficiency.

• 社団法人日本循環器学会の論文
• 2006-05-20

著者

• FUJIWARA TAKAKO

  Department of Pediatrics, Faculty of Medicine, Kyoto University

• 岡田 正彦

  新潟大学大学院予防医療学分野

• 藤原 久義

  岐阜大学第二内科

• 岡田 正彦

  Department Of Cardiology Gifu University Graduate School Of Medicine

• 岡田 正彦

  新潟大学医歯学総合病院検査部

• MINATOGUCHI Shinya

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• TAKEMURA Genzou

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• FUJIWARA Hisayoshi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Fujiwara Takako

  Department Of Food Science Kyoto Women's University

• KANAMORI Hiromitsu

  Division of Cardiology, Gifu University Graduate School of Medicine

• LI Longhu

  Division of Cardiology, Gifu University Graduate School of Medicine

• Maruyama Rumi

  Division Of Cardiology Gifu University Graduate School Of Medicine

• Maruyama Rumi

  岐阜大学 病態情報解析医学

• Maruyama Rumi

  岐阜大学 医学部第二内科

• Kanamori Hiromitsu

  Division Of Cardiology Gifu University Graduate School Of Medicine

• Li Longhu

  Division Of Cardiology Gifu University Graduate School Of Medicine

• 岡田 正彦

  新潟大学 医学部 検査診断学講座

• Ogino Atsushi

  Division of Cardiology, Gifu University Graduate School of Medicine

• MARUYAMA Rumi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Ogino Atsushi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Kanamori Hiromitsu

  Second Department of Internal Medicine, Gifu University School of Medicine

• Li Yiwen

  Second Department of Internal Medicine, Gifu University School of Medicine

• Li Longhu

  Second Department of Internal Medicine, Gifu University School of Medicine

• Okada Hideshi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Esaki Masayasu

  Second Department of Internal Medicine, Gifu University School of Medicine

• Miyata Shusaku

  Second Department of Internal Medicine, Gifu University School of Medicine

• Onogi Hirohito

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Li Yiwen

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Ogino Atsushi

  Division Of Cardiology Gifu University Graduate School Of Medicine

• Miyata Shusaku

  Advanced Critical Care Center Gifu University School Of Medicine

• Koda Masahiko

  Second Department of Internal Medicine, Gifu University School of Medicine

• Kanoh Motoo

  Second Department of Internal Medicine, Gifu University School of Medicine

• Kondo Takehito

  Second Department of Internal Medicine, Gifu University School of Medicine

• 藤原 久義

  岐阜大学 大学院医学研究科東洋医学講座

• Koda Masahiko

  Second Department Of Internal Medicine Faculty Of Medicine Tottori University

• Fujiwara Hisayoshi

  Second Department Of Internal Medicine Gifu University Graduate School Of Medicine

• Fujiwara Takako

  Pediatrics

• Kanoh Motoo

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Ezaki Masayasu

  Department Of Cardiology Gifu University Graduate School Of Medicine

• Okada Hideshi

  Department Of Cardiology Gifu University School Of Medicine

• Minatoguchi Shinya

  Second Department Of Internal Medicine Gifu University Graduate School Of Medicine

• Esaki Masayasu

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Kondo Takehito

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Fujiwara Takako

  Department Of Food Science Kyoto Women's University And The Third Division Department Of Intern

• Fujiwara Hisayoshi

  Second Department Of Internal Medicine Faeulty Of Medicine Gifu University

• Miyata Shusaku

  Second Dep. Of Internal Medicine Graduate School Of Medicine Gifu Univ.

• Takemura Genzou

  Second Dep. Of Internal Medicine Graduate School Of Medicine Gifu Univ.

関連論文

• ECHOCARDIOGRAPHIC ASSESSMENT OF Qp/Qs IN CHILDREN WITH ATRIAL SEPTAL DEFECT OR PARTIAL ANOMALOUS PULMONARY VENOUS CONNECTION
• クメンヒドロペルオキシド/ヘモグロビン・メチレンブルー法における茶とワインの抗酸化反応とその抗酸化能
• Meropenem を含む各種注射用抗菌薬に対する2006年臨床分離株の感受性サーベイランス
• Meropenem を含む各種注射用抗菌薬に対する2004年臨床分離株の感受性サーベイランス
• 呼吸器感染症患者分離菌の薬剤感受性について : 2004年
• 呼吸器感染症患者分離菌の薬剤感受性について(2003年)
• 呼吸器感染症患者分離菌の薬剤感受性について (2002年)
• 呼吸器感染症患者分離菌の薬剤感受性について(2001年)
• 2000年に全国37施設から分離された臨床分離株8,474株の各種抗菌薬に対する感受性サーベイランス
• PJ-807 Color-coded Maps of Multi-detector Row Computed Tomography for Tissue Characterization of Coronary Arteries(PJ135,CT/MRI (Coronary/Vascular) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-354 Validation of Speckle Tracking Imaging in Measurement of Left Atrial and Left Atrial Appendage Function Using Transthoracic and Transesophageal Echocardiography(PJ060,Echo/Doppler (New Technology) 4 (I),Poster Session (Japanese),The 73rd Annual Sci
• PJ-211 Left Atrial Appendage Function and Left Atrial Function by Velocity Vector Imaging as New Predictor for Thrombus in Atrial Fibrillation(PJ036,Echo/Doppler (New Technology) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Ja
• OE-335 Impact of Tissue Characteristics of Coronary Plaque on Distal Embolization after Stent Deployment Evaluated by Integrated Backscatter Intravascular Ultrasound (IB-IVUS)(OE57,Intravascular Imagings (I),Oral Presentation (English),The 73rd Annual Sci
• OE-334 Longitudinal Distribution of Lipid Pools in Coronary Plaques Evaluated by Three-dimensional Integrated Backscatter Intravascular Ultrasound (3D IB-IVUS)(OE57,Intravascular Imagings (I),Oral Presentation (English),The 73rd Annual Scientific Meeting
• Simvastatin reduces myocardial infarct size via increased nitric oxide production in normocholesterolemic rabbits
• Transcatheter embolization by autologous blood clot is useful management for small side branch perforation due to percutaneous coronary intervention guide wire
• Tissue Characterization of Coronary Plaques : Comparison of Integrated Backscatter Intravascular Ultrasound With Virtual Histology Intravascular Ultrasound
• Can negative cardiac effect of proton pump inhibitor and high-dose H2-blocker have clinical influence on patients with stable angina?
• Conservative Medication Follow-up for Over 20 Years of a Patient With Ischemic Heart Disease After Diagnosis of Chronic Total Occlusion of the 3 Main Coronary Arteries
• PJ-714 Relationship between Coronary Artery Distensibility and Tissue Characteristics Evaluated by Three-dimensional Integrated Backscatter Intravascular Ultrasound (3D IB-IVUS)(Intravascular endoscopy / Intravascular ultrasound(07)(I),Poster Session(Japa
• PJ-487 Evaluation of the Left Atrial Myocardium using Integrated Bachscatter Transesophageal Echocardiography(Echo/Doppler(15)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-439 Tissue Characteristics at the Sites of Backward Attenuation of Ultrasound Signals Evaluated by Integrated Backscatter Intravascular Ultrasound(Intravascular endoscopy/Intravascular ultrasound(04)(I),Poster Session(English),The 72nd Annual Scientifi
• Renoprotective Effect of the Addition of Losartan to Ongoing Treatment with an Angiotensin Converting Enzyme Inhibitor in Type-2 Diabetic Patients with Nephropathy
• Reduction of QTc Dispersion by the Angiotensin II Receptor Blocker Valsartan May Be Related to Its Anti-Oxidative Stress Effect in Patients with Essential Hypertension
• PJ-474 Detection of Coronary Atherosclerotic Plaques by Multi-detector Row Computed Tomography : Comparison to Integrated Backscatter Intravascular Ultrasound(CT/DSA-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-359 Noninvasive Evaluation of Tissue Characteristics of Left Atrium with Atrial Fibrillation by Using Three Dimensional Integrated Backscatter Transesopageal Echography (IB-TEE)(Echo/Doppler-17, The 71st Annual Scientific Meeting of the Japanese Circul
• OE-036 Longitudinal Assessment of Tissue Characteristics of Coronary Plaques by Use of Three-Dimensional Integrated Backscatter Intravascular Ultrasound (3D IB-IVUS)(Coronary revascularization, PCI-01, The 71st Annual Scientific Meeting of the Japanese Ci
• FRS-114 Comparisons of Diagnostic Accuracies between Integrated Backscatter Intravascular Ultrasound and Virtual Histology Intravascular Ultrasound for Tissue Characterization of Coronary Plaques(IVUS, OCT and Angioscopy (clinical), The 71st Annual Scient
• Granulocyte Colony-Stimulating Factor : A Noninvasive Regeneration Therapy for Treating Atherosclerotic Peripheral Artery Disease
• PJ-723 The Anti-Diabetic Drug Voglibose Reduces Myocardial Infarct Size and Improves Left Ventricular Function via Production of Glucagon-like Peptide-1 in Rabbits(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 7
• PE-228 Migritol Improve Myocardial Ischemia in Type 2 Diabetic Patients with Coronary Artery Disease(Nuclear cardiology(04)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-184 The anti-Diabetic Drug Pioglitazone Reduces Myocardial Infarct Size by Stimulating PPARγ, PI3K and Akt in Rabbits Model of Myocardial Infarction(Myocardial ischemia / reperfusion, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annu
• OE-182 Oxytocin reduces myocardial infarct size and improves left ventricular function and remodeling through activation of Akt, VEGF, BCI-2 and Angiogenesis(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
• OE-070 Post-Infarct Treatment with an Erythropoietin-Gelatin Hydrogel Patchlmproves Cardiac Function by Activating Prosurvival Signaling and exerting Antifibrotic and Angiogenic Effects(Genetics/Genetically engineered models/Gene therapy(M),Oral Presentat
• OJ-254 Erythropoietin Drug Delivery System protects the heart against myocardial infarction through activation of Akt and angiogenesis(Growth factor/Cytokine-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-267 Relationship between Tissue Components of Coronary Plaques and Their Morphological Parameters : Analysis by Integrated Backscatter Intravascular Ultrasound(Intravascular endoscopy/Intravascular ultrasound-2 (I) OJ45,Oral Presentation (Japanese),The
• PJ-354 Validation of Speckle Tracking Imaging in Measurement of Left Atrial and Left Atrial Appendage Function Using Transthoracic and Transesophageal Echocardiography(PJ060,Echo/Doppler (New Technology) 4 (I),Poster Session (Japanese),The 73rd Annual Sci
• PJ-211 Left Atrial Appendage Function and Left Atrial Function by Velocity Vector Imaging as New Predictor for Thrombus in Atrial Fibrillation(PJ036,Echo/Doppler (New Technology) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Ja
• OE-335 Impact of Tissue Characteristics of Coronary Plaque on Distal Embolization after Stent Deployment Evaluated by Integrated Backscatter Intravascular Ultrasound (IB-IVUS)(OE57,Intravascular Imagings (I),Oral Presentation (English),The 73rd Annual Sci
• OE-334 Longitudinal Distribution of Lipid Pools in Coronary Plaques Evaluated by Three-dimensional Integrated Backscatter Intravascular Ultrasound (3D IB-IVUS)(OE57,Intravascular Imagings (I),Oral Presentation (English),The 73rd Annual Scientific Meeting
• PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
• Water Extract of the Root of Lindera strychnifolia Slows Down the Progression of Diabetic Nephropathy in db/db Mice (Kidney/Renal Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Apoptotic Cell Loss Following Cell Proliferation in Renal Glomeruli of Otsuka Long-Evans Tokushima Fatty Rats
• PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
• PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
• PE-187 Sustained Release of Granulocyte Colony-Stimulating Factor Using Biodegradable Gelatin Hydrogel Improves Limb Ischemia(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Me
• 3 Morphological Characterization and Functional Significance of Starvation-induced Autophagy in Cardiac Myocytes(Cardiomyocyte Death and Cardiac Remodeling,Symposium 9 (SY-09) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-723 The Anti-Diabetic Drug Voglibose Reduces Myocardial Infarct Size and Improves Left Ventricular Function via Production of Glucagon-like Peptide-1 in Rabbits(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 7
• PJ-114 Erythropoietin Receptor Signaling Mitigates Renal Dysfunction-Associated Heart Failure through Direct Cardioprotective Actions Independent of Erythrogenesis(Heart failure, basic(05)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
• OJ-184 The anti-Diabetic Drug Pioglitazone Reduces Myocardial Infarct Size by Stimulating PPARγ, PI3K and Akt in Rabbits Model of Myocardial Infarction(Myocardial ischemia / reperfusion, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annu
• OJ-106 Morphological Characterization of Basal and Starvation-induced Autophagy in Isolated Adult Rat Cardiomyocytes(Cell death, apoptosis/necrosis(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-070 Post-Infarct Treatment with an Erythropoietin-Gelatin Hydrogel Patchlmproves Cardiac Function by Activating Prosurvival Signaling and exerting Antifibrotic and Angiogenic Effects(Genetics/Genetically engineered models/Gene therapy(M),Oral Presentat
• OJ-314 Drug Delivery System Using Erythropoietin Gelatin Hydrogel Sheet Decreases Myocardial Infarct Size and Improves Left Ventricular Function and Remodeling(Growth factor/Cytokine-1 (H) OJ53,Oral Presentation (Japanese),The 70th Anniversary Annual Scie
• PJ-225 Tropomyosin as One of the Earliest Target of Apoptotic Proteolysis Facilitating Cytoskeletal Catastrophe in Cardiac Myocytes(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
• OJ-508 Autophagy, but Not Apoptosis, May be the Mode of Myocyte Death in Hearts of the Cardiomyopathic UM-X7.1 Strain Hamster(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese))
• PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
• PE-078 Pravastatin Reduces Myocardial Infarct Size Through Nitric Oxide Production, Protein Kinase C Activation, Mitochondrial KATP Channel Opening and Decreasing Oxyradicals(Cardiovascular pharmacology, basic/clinical-3 (H) PE13,Poster Session (English),
• Accelerated Post-infarct Neovascularization and Tissue Repair by Chemotherapy-combined G-CSF May Be Related to Peripheral CD34^+ Cells Increased via CXCR4-SDF-1 Axis(Apoptosis/Necrosis/Regeneration 1 (M), The 69th Annual Scientific Meeting of the Japanese
• PE-270 Intravenous Transplantation of Autologous Bone Marrow-Derived Mononuclear Cells Improves Cardiac Function via Downregulation of TGF-beta and TNF-alpha in Ischemia-Reperfusion Hearts.(Transplantation 1 (M) : PE46)(Poster Session (English))
• OE-110 G-CSF after Transient Myelosuppression Improves Cardiac Function via More Myocardial Regeneration and Vasculogenesis than G-CSF Alone in Ischemia-Reperfusion Hearts(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
• Nuclear Hypertrophy Reflects Increased Biosynthetic Activities in Myocytes of Human Hypertrophic Hearts(Clinical Investigation)
• PE-304 Molecular Mechanisms for Beneficial Effects of Fas Signal Inhibition by the Soluble Fas Gene Therapy on Doxorubicin-induced Cardiomyopathy(Cardiomyopathy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-246 Angiotensin II Type 1 Receptor Blockade Inhibits Fas Expression and Apoptosis of Postinfarction Granulation Tissue Cells(Heart failure, basic-2 The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-404 Angiotensin II Type 1 Receptor Blocker improves Postinfarction Ventricular Remodeling by Inhibition of Granulation Tissue Cell Apoptosis(Heart failure, basic-5 (M) PJ68,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the
• PE-466 G-CSF Improves Cardiac Function of Nonischemic Cardiomyopathy Induced by Doxorubicin(Heart failure, basic-3 (M) PE78,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OE-131 G-CSF Displays Its Beneficial Effects on Postinfarction Cardiac Function by Cardiomyocyte Hypertrophy and Anti-fibrosis, but Not by Angiogenesis, Regeneration(Heart failure, basic-1 (M) OE22,Oral Presentation (English),The 70th Anniversary Annual S
• 3 Preventive Effect of Erythropoietin on Cardiac Dysfunction in Doxorubicin-induced Cardiomyopathy(Young Investigator's Award for International Students Finalists Lecture,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Hepatocyte Growth Factor Gene Therapy Improves Cardiac Function of Doxorubicin-induced Cardiomyopathy(Gene Therapy 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Morphological Basis for Imapact of Angiotensin II Type 1A Receptor Blockade upon Myocardial Infarct Tissue Dynamics(Heart Failure, Basic 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Erythropoietin Improves Cardiac Function of Doxorubicin-induced Cardiomyopathy(Cardiac Hypertrophy/Cardiomyopathy 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Soluble Fas Gene Therapy Improves Cardiac Function of Doxorubicin-induced Cardiomyopathy, Independently of Cardiomyocyte Apoptosis(Cardiomyopathy, Basic (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OE-264 Autophagic Cardiomyocyte Death in Cardiomyopathic Hamsters and Its Prevention by Granulocyte Colony-Stimulating Factor(Cardiomyopathy, basic/clinical-1 (M) OE45,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japan
• Modification of Post-Myocardial Infarction Granulocyte-Colony Stimulating Factor Therapy With Myelosuppressives
• CLINICOPATHOLOGIC STUDY OF ABNORMAL Q WAVES IN KAWASAKI DISEASE : MUCOCUTANEOUS LYMPH NODE SYNDROME : Electrocardiography : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
• PE-428 Cyclophosphamide Improves Left Ventricular Dysfunction in Post-MI Chronic Heart Failure by Downregulating Inflammatory Cytokine and MMP(Heart failure, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-082 5-Fluorouracil Improves Postinfarct Left Ventricular Dysfunction due to Upregulated SDF-1, Mobilized CD34 Positive Cells and Attenuated Fibrosis(Acute myocardial infarction, basic-1 (IHD) OE14,Oral Presentation (English),The 70th Anniversary Annual
• Infarct Size and the Protection of Ischemic Myocardium in Pig, Dog and Human : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research
• DISTRIBUTION AND PROGRESSION OF CORONARY ARTERIAL AND AORTIC LESIONS IN THE CONVENTIONAL WATANABE HERITABLE HYPERLIPIDEMIC RABBIT : Quantitative Analysis
• Ubiquitous Expression of Stem Cell Antigen-1 in Cardiac Endothelium (Apoptosis/Necrosis/Regeneration 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-386 Combination Thearpy of Antiapoptosis and Regeneration against Postinfarct Heart Failure : A Novel Therapeutic Concept(Old Myocardial Infarction/Remodeling 3 (IHD) : PE66)(Poster Session (English))
• Cyclophosphamide Improves the Function of Post-Infarct Hearts by Reducing Old Infarct Area and Accelerating the Mobilization of CD34^+ Cells
• OE-324 Postinfarction Gene Transfer of Soluble TGF-β Typed Receptor Relieves Heart Failure during the Chronic Stage of Myocardial Infarction(Gene Therapy 2 (IHD) : OE41)(Oral Presentation (English))
• Gene Transfer of Soluble TGF-β Type II Receptor Suppresses Cardiac Fibrosis and Improves Cardiac Function in Cardiomyopathic Hamsters
• Elucidation of the Roles of HB-EGF in the Heart by the Overexpression of HB-EGF
• Critical roles of the Fas/Fas ligand system for post-infarct ventricular remodeling and heart failure
• Injection of an adenoviral vector expressing hepatocyte growth factor into skeletal muscle after myocardial infarction relieves post-infarct heart failure
• Intravenous transplantation of autologuos bone marrow cells after myocardial infarction regenerates cardiomyocytes and improvescardiac function in rabbit hearts
• CLINICOPATHOLOGICAL STUDY OF VALVULAR REGURGITATION IN KAWASAKI DISEASE : Congenital Heart Disease, Kawasaki Disease : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Abundant apoptosis in nutmeg liver of cardiomyopathic hamsters : Apoptotic cell death as a possible mechanism of hepatic remodeling by congestion
• -135- RELATION BETWEEN MYOCARDIAL INFARCTION AND THE INFARCT-RELATED ARTERY IN THE HEALED STAGE OF KAWASAKI DISEASE : Congenital Heart Disease, Kawasaki Disease : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE C
• Ultrastructure of regenerated cardiac cells after myocardial infarction : Differentiation, proliferation, and apoptosis
• NUMBER AND SIZE OF MYOCYTES, AMOUNT OF INTERSTITIAL SPACE AND EXTENT OF DISARRAY OF THE HEARTS IN PATIENTS WITH SYSTEMIC HYPERTENSION AND ASYMMETRIC SEPTAL HYPERTROPHY
• Myocardial Apoptosis Index Based on DNA in Situ Nick End-Labeling (TUNEL) Can not Predict Prognosis of Patients with Dilated Cardiomyopathy
• Myocytes Positive for in Situ Markers for DNA Breaks in Hypertrophic, but Neither Failed Nor Dilated, Human Hearts
• Granulocyte-Colony Stimulating Factor (G-CSF) Prevents Myocardial Fibrosis and Heart Failure in Cardiomyopathic Hamsters
• Fluctuation of Intracellular Ca^ through Multiple Ca^ Regulatory Proteins May Be Inevitable for Initiating Apoptosls in Adult Cardiac Myocytes
• Nifedipine prevents Fas-associated and β-adrenergic pathway-induced apoptosis and apoptotic beating at the early phase in cultured adult cardiomyocytes
• Nuclear phenotype alteration reflects increased biosynthetic activities in human hypertrophic cardiac myocytes
• Apoptosis, Rather Than Oncosis, is the Predominant Mode of Spontaneous Death of Isolated Adult Rat Cardiac Myocytes in Culture
• SIZE OF CORONARY ANEURYSM AS A DETERMINING FACTOR OF THE PROGNOSIS IN KAWASAKI DISEASE IN STAGE IV : Infective Endocarditis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY

もっと見る 閉じる

スポンサーリンク