Apoptosis, Rather Than Oncosis, is the Predominant Mode of Spontaneous Death of Isolated Adult Rat Cardiac Myocytes in Culture
スポンサーリンク
概要
- 論文の詳細を見る
A number of isolated adult cardiomyocytes dies within a few days of culture and the mode of death has recently been suggested to be apoptosis, based on its association with the appearance of DNA fragmentation. However, morphological evidence is still lacking and precise analysis, including quantification, has not been performed. Adult rat ventricular cardiomyocytes isolated by enzymatic dissociation were incubated for 7 days in a serum-free medium (the rapid attachment model) and after various incubation periods, both attached and floating cells were counted and classified based on combined criteria of morphology and membrane permeability (dye exclusion): type 1, rod cells with intact membranes; type 2, non-rod cells with intact membranes; and type 3, non-rod cells with ruptured membranes. The number of both rod-shaped and dye-excluding cells decreased with the incubation period. After 7 days culture, the number of residual cells decreased to 12% of the initial value. Electron microscopy identified type 1 cells as viable, type 2 cells as viable or apoptotic, and type 3 as undergoing oncosis (primary necrosis) or secondary post-apoptotic necrosis. Ultrastructural morphometry revealed that oncotic cell death occurred predominantly during the early phase of culture whereas the more abundant apoptotic cell death occurred throughout the culture period. In conclusion, although both apoptotic and oncotic death occur in the natural course of adult rat cardiomyocytes in short-term culture, apoptosis is more predominant. Because of the high incidence of spontaneous cell death predominantly via apoptosis, this information is important for the interpretation of studies using this cell type in culture.
- 社団法人日本循環器学会の論文
- 2001-07-20
著者
-
FUJIWARA TAKAKO
Department of Pediatrics, Faculty of Medicine, Kyoto University
-
MINATOGUCHI Shinya
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
-
AOYAMA Takuma
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
-
TAKEMURA Genzou
Second Department of Internal Medicine, Gifu University Graduate School of Medicine
-
FUJIWARA Hisayoshi
Second Department of Internal Medicine, Gifu University School of Medicine
-
Fujiwara Takako
Department Of Food Science Kyoto Women's University
-
Maruyama Rumi
岐阜大学 病態情報解析医学
-
Maruyama Rumi
岐阜大学 医学部第二内科
-
MARUYAMA Rumi
Second Department of Internal Medicine, Gifu University School of Medicine
-
Li Yiwen
Second Department Of Internal Medicine Gifu University School Of Medicine
-
Koda Masahiko
Second Department of Internal Medicine, Gifu University School of Medicine
-
Aoyama Takuma
Department Of Cardiology Gifu University Graduate School Of Medicine
-
Koda Masahiko
Second Department Of Internal Medicine Faculty Of Medicine Tottori University
-
Kawase Yukinori
Department Of Cardiology Gifu University Graduate School Of Medicine
-
Hayakawa Kenji
Cardiology, Respirology and Nephrology, Gifu University Graduate School of Medicine
-
Hayakawa Kenji
Second Department of Internal Medicine, Gifu University School of Medicine
-
Kawase Yukinori
Second Department of Internal Medicine, Gifu University School of Medicine
-
Fujiwara Hisayoshi
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
-
Minatoguchi Shinya
Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
-
Hayakawa Kenji
Second Department Of Internal Medicine Gifu University School Of Medicine
-
Aoyama Takuma
Second Department Of Internal Medicine Gifu University School Of Medicine
-
Kato Satoshi
Second Department of Internal Medicine, Gifu University School of Medicine
-
Fujiwara Hisayoshi
Second Department Of Internal Medicine Faeulty Of Medicine Gifu University
-
Kato Satoshi
Second Department Of Internal Medicine Gifu University School Of Medicine
-
Takemura Genzou
Second Dep. Of Internal Medicine Graduate School Of Medicine Gifu Univ.
関連論文
- ECHOCARDIOGRAPHIC ASSESSMENT OF Qp/Qs IN CHILDREN WITH ATRIAL SEPTAL DEFECT OR PARTIAL ANOMALOUS PULMONARY VENOUS CONNECTION
- Transcatheter embolization by autologous blood clot is useful management for small side branch perforation due to percutaneous coronary intervention guide wire
- Can negative cardiac effect of proton pump inhibitor and high-dose H2-blocker have clinical influence on patients with stable angina?
- Conservative Medication Follow-up for Over 20 Years of a Patient With Ischemic Heart Disease After Diagnosis of Chronic Total Occlusion of the 3 Main Coronary Arteries
- Renoprotective Effect of the Addition of Losartan to Ongoing Treatment with an Angiotensin Converting Enzyme Inhibitor in Type-2 Diabetic Patients with Nephropathy
- Reduction of QTc Dispersion by the Angiotensin II Receptor Blocker Valsartan May Be Related to Its Anti-Oxidative Stress Effect in Patients with Essential Hypertension
- PJ-723 The Anti-Diabetic Drug Voglibose Reduces Myocardial Infarct Size and Improves Left Ventricular Function via Production of Glucagon-like Peptide-1 in Rabbits(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 7
- PE-228 Migritol Improve Myocardial Ischemia in Type 2 Diabetic Patients with Coronary Artery Disease(Nuclear cardiology(04)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-184 The anti-Diabetic Drug Pioglitazone Reduces Myocardial Infarct Size by Stimulating PPARγ, PI3K and Akt in Rabbits Model of Myocardial Infarction(Myocardial ischemia / reperfusion, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annu
- OE-182 Oxytocin reduces myocardial infarct size and improves left ventricular function and remodeling through activation of Akt, VEGF, BCI-2 and Angiogenesis(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
- OE-070 Post-Infarct Treatment with an Erythropoietin-Gelatin Hydrogel Patchlmproves Cardiac Function by Activating Prosurvival Signaling and exerting Antifibrotic and Angiogenic Effects(Genetics/Genetically engineered models/Gene therapy(M),Oral Presentat
- Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits
- OJ-254 Erythropoietin Drug Delivery System protects the heart against myocardial infarction through activation of Akt and angiogenesis(Growth factor/Cytokine-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
- Water Extract of the Root of Lindera strychnifolia Slows Down the Progression of Diabetic Nephropathy in db/db Mice (Kidney/Renal Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Hydroxyl Radical Generation by the Combination of Iron and Ascorbic Acid is Greatly Attenuated but Still Significant in Human Grastric Juice
- Apoptotic Cell Loss Following Cell Proliferation in Renal Glomeruli of Otsuka Long-Evans Tokushima Fatty Rats
- PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
- PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
- PE-187 Sustained Release of Granulocyte Colony-Stimulating Factor Using Biodegradable Gelatin Hydrogel Improves Limb Ischemia(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Me
- 3 Morphological Characterization and Functional Significance of Starvation-induced Autophagy in Cardiac Myocytes(Cardiomyocyte Death and Cardiac Remodeling,Symposium 9 (SY-09) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-723 The Anti-Diabetic Drug Voglibose Reduces Myocardial Infarct Size and Improves Left Ventricular Function via Production of Glucagon-like Peptide-1 in Rabbits(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 7
- PJ-114 Erythropoietin Receptor Signaling Mitigates Renal Dysfunction-Associated Heart Failure through Direct Cardioprotective Actions Independent of Erythrogenesis(Heart failure, basic(05)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
- PE-117 Sustained Release of Erythropoietin Using Biodegradable Gelatin Hydrogel Persistently Improves Lower Leg Ischemia without Evoking Polycytemia(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting
- OJ-184 The anti-Diabetic Drug Pioglitazone Reduces Myocardial Infarct Size by Stimulating PPARγ, PI3K and Akt in Rabbits Model of Myocardial Infarction(Myocardial ischemia / reperfusion, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annu
- OJ-106 Morphological Characterization of Basal and Starvation-induced Autophagy in Isolated Adult Rat Cardiomyocytes(Cell death, apoptosis/necrosis(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-070 Post-Infarct Treatment with an Erythropoietin-Gelatin Hydrogel Patchlmproves Cardiac Function by Activating Prosurvival Signaling and exerting Antifibrotic and Angiogenic Effects(Genetics/Genetically engineered models/Gene therapy(M),Oral Presentat
- OJ-314 Drug Delivery System Using Erythropoietin Gelatin Hydrogel Sheet Decreases Myocardial Infarct Size and Improves Left Ventricular Function and Remodeling(Growth factor/Cytokine-1 (H) OJ53,Oral Presentation (Japanese),The 70th Anniversary Annual Scie
- Relation between Various Risk Factors and Tissue Characterization of Atherosclerosis in Coronary Arteries : An Integrated Backscatter Intravascular Ultrasound Study(Intravascular Endoscopy/Intravascular Ultrasound 4 (I), The 69th Annual Scientific Meeting
- PJ-225 Tropomyosin as One of the Earliest Target of Apoptotic Proteolysis Facilitating Cytoskeletal Catastrophe in Cardiac Myocytes(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
- OJ-508 Autophagy, but Not Apoptosis, May be the Mode of Myocyte Death in Hearts of the Cardiomyopathic UM-X7.1 Strain Hamster(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese))
- Different Effects of Various Statins on Medial Sclerosis of Carotid Arteries as Assessed by Integrated Backscatter Ultrasound and Histological Meanings
- Volumetric Analysis for Tissue Characterization of Coronary Plaques by Use of Three-Dimensional Integrated Backscatter Intravascular Ultrasound (3D IB-IVUS)
- Relation between Various Risk Factors and Tissue Characterization of Atherosclerosis in Coronary Arteries : An Integrated Backscatter Intravascular Ultrasound Study(Intravascular Endoscopy/Intravascular Ultrasound 4 (I), The 69th Annual Scientific Meeting
- PJ-048 Erythropoietin Receptor Signaling Promotes Neointimal Hyperplasia in the Balloon-Injured Rat Carotid Artery(PJ008,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese C
- Sarpogrelate, a 5-HT_2 Receptor Blocker, may Have a Preconditionieg-Like Effect in Patients With Coronary Artery Disease
- Celiprolol, a Selective β_1-Blocker, Reduces the Infarct Size Through Production of Nitric Oxide in a Rabbit Model of Myocardial Infarction
- Nicorandil Improves Post-Ischemic Myocardial Dysfunction in Association With Opening the Mitochondrial KATP Channels and Decreasing Hydroxyl Radicals in Isolated Rat Hearts
- PE-078 Pravastatin Reduces Myocardial Infarct Size Through Nitric Oxide Production, Protein Kinase C Activation, Mitochondrial KATP Channel Opening and Decreasing Oxyradicals(Cardiovascular pharmacology, basic/clinical-3 (H) PE13,Poster Session (English),
- Cilnidipine, an N+L-Type Dihydropyridine Ca Channel Blocker, Suppresses the Occurrence of Ischemia/Reperfusion Arrhythmia in a Rabbit Model of Myocardial Infarction
- Accelerated Post-infarct Neovascularization and Tissue Repair by Chemotherapy-combined G-CSF May Be Related to Peripheral CD34^+ Cells Increased via CXCR4-SDF-1 Axis(Apoptosis/Necrosis/Regeneration 1 (M), The 69th Annual Scientific Meeting of the Japanese
- PE-270 Intravenous Transplantation of Autologous Bone Marrow-Derived Mononuclear Cells Improves Cardiac Function via Downregulation of TGF-beta and TNF-alpha in Ischemia-Reperfusion Hearts.(Transplantation 1 (M) : PE46)(Poster Session (English))
- OE-110 G-CSF after Transient Myelosuppression Improves Cardiac Function via More Myocardial Regeneration and Vasculogenesis than G-CSF Alone in Ischemia-Reperfusion Hearts(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
- Ameliorating Effect of Autologous Bone Marrow Cell Transplantation in Rabbit Hearts with Cardiomyopathy
- J-SAP Study 1-2: Outcomes of Patients With Stable High-Risk Coronary Artery Disease Receiving Medical-Preceding Therapy in Japan : A Comparison With CABG-Preceding Therapy
- Nuclear Hypertrophy Reflects Increased Biosynthetic Activities in Myocytes of Human Hypertrophic Hearts(Clinical Investigation)
- Caspase-Dependent and Serine Protease-Dependent DNA Fragmentation of Myocytes in the Ischemia-Reperfused Rabbit Heart : These Inhibitors Do Not Reduce Infarct Size
- Evidence of a Cellular Protective Effect by Antecedent Angina Independent of Collateral Flow Recruitment During Coronary Angioplasty in Humans
- PE-304 Molecular Mechanisms for Beneficial Effects of Fas Signal Inhibition by the Soluble Fas Gene Therapy on Doxorubicin-induced Cardiomyopathy(Cardiomyopathy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-246 Angiotensin II Type 1 Receptor Blockade Inhibits Fas Expression and Apoptosis of Postinfarction Granulation Tissue Cells(Heart failure, basic-2 The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-404 Angiotensin II Type 1 Receptor Blocker improves Postinfarction Ventricular Remodeling by Inhibition of Granulation Tissue Cell Apoptosis(Heart failure, basic-5 (M) PJ68,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the
- PE-466 G-CSF Improves Cardiac Function of Nonischemic Cardiomyopathy Induced by Doxorubicin(Heart failure, basic-3 (M) PE78,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-131 G-CSF Displays Its Beneficial Effects on Postinfarction Cardiac Function by Cardiomyocyte Hypertrophy and Anti-fibrosis, but Not by Angiogenesis, Regeneration(Heart failure, basic-1 (M) OE22,Oral Presentation (English),The 70th Anniversary Annual S
- 3 Preventive Effect of Erythropoietin on Cardiac Dysfunction in Doxorubicin-induced Cardiomyopathy(Young Investigator's Award for International Students Finalists Lecture,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Hepatocyte Growth Factor Gene Therapy Improves Cardiac Function of Doxorubicin-induced Cardiomyopathy(Gene Therapy 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Morphological Basis for Imapact of Angiotensin II Type 1A Receptor Blockade upon Myocardial Infarct Tissue Dynamics(Heart Failure, Basic 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Erythropoietin Improves Cardiac Function of Doxorubicin-induced Cardiomyopathy(Cardiac Hypertrophy/Cardiomyopathy 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Soluble Fas Gene Therapy Improves Cardiac Function of Doxorubicin-induced Cardiomyopathy, Independently of Cardiomyocyte Apoptosis(Cardiomyopathy, Basic (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-158 Cationized Gelatin Delivery of a Plasmid Encoding Soluble Fas Mitigates Postinfarction Left Ventricular Remodeling(Acute myocardial infarction, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-264 Autophagic Cardiomyocyte Death in Cardiomyopathic Hamsters and Its Prevention by Granulocyte Colony-Stimulating Factor(Cardiomyopathy, basic/clinical-1 (M) OE45,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japan
- Modification of Post-Myocardial Infarction Granulocyte-Colony Stimulating Factor Therapy With Myelosuppressives
- PJ-781 Cross-Talk between Nitric Oxide and Hydroxyl Radicals is Involved in the Reduction of Infarct Size By Edaravone(Myocardial ischemia-reperfusion, basic/clinical-6 (IHD) PJ136,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting o
- CLINICOPATHOLOGIC STUDY OF ABNORMAL Q WAVES IN KAWASAKI DISEASE : MUCOCUTANEOUS LYMPH NODE SYNDROME : Electrocardiography : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- OE-204 Total Spasm Provoked by Ergonovine is an Important Prognostic Factor on Cardiovascular Events in Patients with Vasospastic Angina(Coronary circulation, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Jap
- OE-025 Benidipine Significantly Prevented Cardiovascular Events Compared to Diltiazem in Patients With Vasospastic Angina(Cardiovascular pharmacology, basic/clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circ
- PE-428 Cyclophosphamide Improves Left Ventricular Dysfunction in Post-MI Chronic Heart Failure by Downregulating Inflammatory Cytokine and MMP(Heart failure, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-082 5-Fluorouracil Improves Postinfarct Left Ventricular Dysfunction due to Upregulated SDF-1, Mobilized CD34 Positive Cells and Attenuated Fibrosis(Acute myocardial infarction, basic-1 (IHD) OE14,Oral Presentation (English),The 70th Anniversary Annual
- Cardiomyopathy with Prominent Autophagic Degeneration, Accompanied by an Elevated Plasma Brain Natriuretic Peptide Level Despite the Lack of Overt Heart Failure
- In Vivo Quantitative Tissue Characterization of Angiographically Normal Coronary Segment (ANS) Assessed by Integrated Backscatter Intravascular Ultrasound (IB-IVUS)
- Quantitative Tissue Characterization of Coronary Plaques with Progression Assessed by Integrated Backscatter Intravascular Ultrasound (IB-IVUS)
- Vasopressin Inhibits Sarcolemmal ATP-Sensitive K+ Channels via V_1 Receptors Activation in the Guinea Pig Heart
- Sesquiterpene Lactone Suppresses Vascular Smooth Muscle Cell Proliferation and Migration via Inhibition of Cell Cycle Progression(Pharmacognosy)
- Relationship Between Functional Exercise Capacity and Functional Stenosis in Patients With Stable Angina and Intermediate Coronary Stenosis
- Over 10 years clinical outcomes in patients with mitral stenosis with unilateral commissural calcification treated with catheter balloon commissurotomy : Single-center experience
- Outcomes of Patients With Stable Low-Risk Coronary Artery Disease Receiving Medical- and PCI-Preceding Therapies in Japan : J-SAP Study 1-1
- Infarct Size and the Protection of Ischemic Myocardium in Pig, Dog and Human : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research
- DISTRIBUTION AND PROGRESSION OF CORONARY ARTERIAL AND AORTIC LESIONS IN THE CONVENTIONAL WATANABE HERITABLE HYPERLIPIDEMIC RABBIT : Quantitative Analysis
- Ubiquitous Expression of Stem Cell Antigen-1 in Cardiac Endothelium (Apoptosis/Necrosis/Regeneration 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-386 Combination Thearpy of Antiapoptosis and Regeneration against Postinfarct Heart Failure : A Novel Therapeutic Concept(Old Myocardial Infarction/Remodeling 3 (IHD) : PE66)(Poster Session (English))
- Cyclophosphamide Improves the Function of Post-Infarct Hearts by Reducing Old Infarct Area and Accelerating the Mobilization of CD34^+ Cells
- Dual blockade of the rennin-angiotensin system versus maximal recommended dose of angiotensin II receptor blockade in chronic glomerulonephritis
- OE-324 Postinfarction Gene Transfer of Soluble TGF-β Typed Receptor Relieves Heart Failure during the Chronic Stage of Myocardial Infarction(Gene Therapy 2 (IHD) : OE41)(Oral Presentation (English))
- Gene Transfer of Soluble TGF-β Type II Receptor Suppresses Cardiac Fibrosis and Improves Cardiac Function in Cardiomyopathic Hamsters
- Elucidation of the Roles of HB-EGF in the Heart by the Overexpression of HB-EGF
- Critical roles of the Fas/Fas ligand system for post-infarct ventricular remodeling and heart failure
- Injection of an adenoviral vector expressing hepatocyte growth factor into skeletal muscle after myocardial infarction relieves post-infarct heart failure
- Intravenous transplantation of autologuos bone marrow cells after myocardial infarction regenerates cardiomyocytes and improvescardiac function in rabbit hearts
- CLINICOPATHOLOGICAL STUDY OF VALVULAR REGURGITATION IN KAWASAKI DISEASE : Congenital Heart Disease, Kawasaki Disease : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Abundant apoptosis in nutmeg liver of cardiomyopathic hamsters : Apoptotic cell death as a possible mechanism of hepatic remodeling by congestion
- -135- RELATION BETWEEN MYOCARDIAL INFARCTION AND THE INFARCT-RELATED ARTERY IN THE HEALED STAGE OF KAWASAKI DISEASE : Congenital Heart Disease, Kawasaki Disease : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE C
- Ultrastructure of regenerated cardiac cells after myocardial infarction : Differentiation, proliferation, and apoptosis
- NUMBER AND SIZE OF MYOCYTES, AMOUNT OF INTERSTITIAL SPACE AND EXTENT OF DISARRAY OF THE HEARTS IN PATIENTS WITH SYSTEMIC HYPERTENSION AND ASYMMETRIC SEPTAL HYPERTROPHY
- Myocardial Apoptosis Index Based on DNA in Situ Nick End-Labeling (TUNEL) Can not Predict Prognosis of Patients with Dilated Cardiomyopathy
- Myocytes Positive for in Situ Markers for DNA Breaks in Hypertrophic, but Neither Failed Nor Dilated, Human Hearts
- Granulocyte-Colony Stimulating Factor (G-CSF) Prevents Myocardial Fibrosis and Heart Failure in Cardiomyopathic Hamsters
- Fluctuation of Intracellular Ca^ through Multiple Ca^ Regulatory Proteins May Be Inevitable for Initiating Apoptosls in Adult Cardiac Myocytes
- Nifedipine prevents Fas-associated and β-adrenergic pathway-induced apoptosis and apoptotic beating at the early phase in cultured adult cardiomyocytes
- Nuclear phenotype alteration reflects increased biosynthetic activities in human hypertrophic cardiac myocytes
- Apoptosis, Rather Than Oncosis, is the Predominant Mode of Spontaneous Death of Isolated Adult Rat Cardiac Myocytes in Culture
- SIZE OF CORONARY ANEURYSM AS A DETERMINING FACTOR OF THE PROGNOSIS IN KAWASAKI DISEASE IN STAGE IV : Infective Endocarditis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY