Cardiomyopathy with Prominent Autophagic Degeneration, Accompanied by an Elevated Plasma Brain Natriuretic Peptide Level Despite the Lack of Overt Heart Failure

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概要

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• A 75-year-old man without overt heart failure showed an abnormally high level of brain natriuretic peptide (BNP) in plasma: 600 pg/ml. The left ventricular endomyocardial biopsy revealed prominent vacuolar degeneration in the myocytes, most of which were positive for PAS stain and BNP immunoreaction. Ultrastructurally, degenerative changes of myocytes were marked, such as deposits of glycogen and lipofuscin granules in the cytoplasm, but the most prominent finding was giant vacuoles containing degraded mitochondria, glycogen granules, myofibrils, and myelin-like structures (autophagosomes). This case may belong to one of the unclassified cardiomyopathies characterized by prominent autophagic vacuoles.

• 社団法人　日本内科学会の論文
• 2004-08-01

著者

• 岡田 正彦

  新潟大学大学院予防医療学分野

• 岡田 正彦

  Department Of Cardiology Gifu University Graduate School Of Medicine

• Saio Masanao

  Department of Immunopathology Gifu University Graduate School of Medicine

• NISHIGAKI Kazuhiko

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• KAWASAKI Masanori

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• MINATOGUCHI Shinya

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• TAKEMURA Genzou

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• FUJIWARA Hisayoshi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Tsuchiya Kunihiko

  Regeneration & Advanced Medical Science Graduate School Of Medicine Gifu University

• Nishigaki Kazuhiko

  岐阜大学 医学系研究科循環病態学

• Gotoh K

  Division Of Cardiology Gifu University Graduate School Of Medicine

• Goto Kazuko

  岐阜大学 病態情報解析医学

• Goto Kazuko

  Second Department Of Internal Medicine Gifu University School Of Medicine

• 岡田 正彦

  新潟大学 医学部 検査診断学講座

• Okada Hideshi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Miyata Shusaku

  Second Department of Internal Medicine, Gifu University School of Medicine

• Tsuchiya Kunihiko

  Second Department of Internal Medicine, Gifu University School of Medicine

• Onogi Hirohito

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Miyata Shusaku

  Advanced Critical Care Center Gifu University School Of Medicine

• Koda Masahiko

  Second Department of Internal Medicine, Gifu University School of Medicine

• 藤原 久義

  岐阜大学 大学院医学研究科東洋医学講座

• Koda Masahiko

  Second Department Of Internal Medicine Faculty Of Medicine Tottori University

• SAIJO Mieko

  Second Department of Internal Medicine, Gifu University School of Medicine

• OHNO Yasushi

  Second Department of Internal Medicine, Gifu University School of Medicine

• GOTO Koshi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Kawasaki Masanori

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Tsuchiya Kunihiko

  Second Department Of Internal Medicine Faeulty Of Medicine Gifu University

• Fujiwara Hisayoshi

  Second Department Of Internal Medicine Gifu University Graduate School Of Medicine

• Ohno Yasushi

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Okada Hideshi

  Department Of Cardiology Gifu University School Of Medicine

• Minatoguchi Shinya

  Second Department Of Internal Medicine Gifu University Graduate School Of Medicine

• Nishigaki Kazuhiko

  Second Department Of Internal Medicine Gifu University

• Gotoh Kohshi

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Fujiwara Hisayoshi

  Second Department Of Internal Medicine Faeulty Of Medicine Gifu University

• Miyata Shusaku

  Second Dep. Of Internal Medicine Graduate School Of Medicine Gifu Univ.

• Takemura Genzou

  Second Dep. Of Internal Medicine Graduate School Of Medicine Gifu Univ.

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