Lactobacillus acidophilus Strain L-92 Induces CD4+CD25+Foxp3+ Regulatory T Cells and Suppresses Allergic Contact Dermatitis
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概要
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The anti-allergic mechanism of heat-killed Lactobacillus acidophilus strain L-92 has not been fully investigated. Recent studies have reported that CD4+CD25+Foxp3+ (forkhead box P3) T regulatory (Treg) cells play important roles in controlling allergic diseases. Hence, we examined the effect of orally administered L-92 on CD4+CD25+Foxp3+ cell populations. BALB/c mice were supplemented daily with L-92 by gavage for 5 weeks. 2,4-Dinitrofluorobenzene (DNFB) was used to induce allergic contact dermatitis (ACD) in mice. Fluorescent-activated cell sorter (FACS) analysis was used to determine CD4+CD25+Foxp3+ T cell populations in spleen and cervical lymph nodes (CLN). Interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and Foxp3 mRNA expressions in mouse ear skin were investigated by real-time reverse transcription-polymerase chain reaction (RT-PCR). The percentage of CD4+CD25+Foxp3+ T cell populations were significantly increased in both spleen and CLN of L-92-fed group than vehicle and control. In addition, L-92 produced higher levels of Foxp3, IL-10 and TGF-β compared to control mice. These results suggest that L-92 can up-regulate the number of Treg cells to suppress the progression of DNFB-induced contact dermatitis in mice.
著者
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Saio Masanao
Department of Immunopathology Gifu University Graduate School of Medicine
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Yamashita Hirotaka
Laboratory Of Biochemistry And Nutritional Chemistry Faculty Of Agriculture Kagoshima University
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Takami Tsuyoshi
Department Of Crystalline Materials Science Nagoya University
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Ezaki Takayuki
Department Of Microbiology Gifu University Graduate School Of Medicine
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Shah Mohammad
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Inagaki Naoki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Tanaka Hiroyuki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Shah Mohammad
Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University
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Inagaki Naoki
Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University
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Yamashita Hirotaka
Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University
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Tanaka Hiroyuki
Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University
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