Effects of SA13353, a Transient Receptor Potential Vanilloid 1 Agonist, on Leukocyte Infiltration in Lipopolysaccharide-Induced Acute Lung Injury and Ovalbumin-Induced Allergic Airway Inflammation
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概要
- 論文の詳細を見る
We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation. In LPS-induced lung injury, SA13353 attenuated neutrophil infiltration and the increase of TNF-α and CINC-1 levels. In allergic airway inflammation, SA13353 tended to inhibit leukocyte infiltration and attenuated the increase of IL-4 and IL-12p40. These results suggest that somatosensory TRPV1 may play an anti-inflammatory role in lung inflammation.
- 社団法人 日本薬理学会の論文
- 2010-04-20
著者
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TANAKA Hiroyuki
Laboratory of Marine Biotechnology and Microbiology, Graduate School of Fisheries Sciences, Hokkaido
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Inagaki Naoki
Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University
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Tsuji Fumio
Research and Development Center, Santen Pharmaceutical Co., Ltd.
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Aono Hiroyuki
Research and Development Center, Santen Pharmaceutical Co., Ltd.
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Aono Hiroyuki
大阪大学 生命機能研究科免疫発生学
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Aono Hiroyuki
Discovery Research Division Santen Pharmaceutical Co. Ltd.
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Tsuji Fumio
Research And Development Center Santen Pharmaceutical Co. Ltd.
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Aono Hiroyuki
Research And Development Center Santen Pharmaceutical Co. Ltd.
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Murai Masaaki
Research and Development Center, Santen Pharmaceutical Co., Ltd., Japan
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Oki Kenji
Research and Development Center, Santen Pharmaceutical Co., Ltd., Japan
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Inoue Hiroyuki
Research and Development Center, Santen Pharmaceutical Co., Ltd., Japan
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Sasano Minoru
Research and Development Center, Santen Pharmaceutical Co., Ltd., Japan
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Sasano Minoru
Nara Research And Development Center Santen Pharmaceutical Co. Ltd.
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Sasano Minoru
Research And Development Center Santen Pharmaceutical Co. Ltd.
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Murai Masaaki
Research And Development Center Santen Pharmaceutical Co. Ltd.
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Oki Kenji
Research And Development Center Santen Pharmaceutical Co. Ltd.
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Inagaki Naoki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Tanaka Hiroyuki
Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University
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Tanaka Hiroyuki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Inoue Hiroyuki
Research And Development Center Santen Pharmaceutical Co. Ltd.
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