Recovery of Purification-Associated Reduction in Antigen-Induced Histamine Release from Rat Peritoneal Mast Cells

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概要

• 論文の詳細を見る

• Immunoglobulin E(IgE)-dependent histamine release from purified rat peritoneal mast cells(PMC)is very low in comparison to that from a non-purified preparation(PEC). The reduced histamine release from PMC is recovered or potentiated by reconstitution with separated non-mast cells(NMC). In the present study, further characterization was undertaken to elucidate the mechanisms involved. Sensitized mast cells were recovered from peritoneal cavities of rats, and purified by density gradient centrifugation with Percoll. Effects of NMC reconstitution, membrane fraction of NMC, NMC incubation supernatant, adhesion molecules and extracellular matrix proteins on IgE-dependent histamine release from PMC were examined. IgE-dependent histamine release was significantly potentiated by NMC reconstitution to PMC. The potentiation was dependent on the concentration of NMC reconstituted and reached a plateau after 30 min incubation. Increasing concentration of PMC did not affect the histamine release. Membrane fraction prepared from NMC also potentiated PMC histamine release in a dose-dependent manner. The potentiation reached a plateau in 5 min. Furthermore, incubation supernatant of NMC potentiated PMC histamine release. Antibodies against intercellular adhesion molecule(ICAM)-1, lymphocyte function-associated antigen(LFA)-1, very late activation antigen(VLA)-1, VLA-4 and VLA-6, and fibronectin did not affect the potentiation of PMC histamine release by NMC reconstitution. Fibronectin, laminin and collagen failed to potentiate PMC histamine release. These results indicate that the membrane component(s)of NMC in the rat peritoneal cavity seems to modulate IgE-dependent histamine release from peritoneal mast cells of rats, and that the active molecule(s)may be released from NMC. Adhesion molecules such as ICAM-1, LFA-1 and VLA are not involved.

• 社団法人日本薬学会の論文
• 2001-07-01

著者

• INAGAKI Naoki

  Department of Pharmacology, Gifu Pharmaceutical University

• NAGAI Hiroichi

  Department of Pharmacology, Gifu Pharmaceutical University

• KIMATA Masahiro

  Department of Pharmacology, Gifu Pharmaceutical University

• Inagaki Naoki

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• NAKAI Noriko

  Department of Pharmacology, Gifu Pharmaceutical University

• KAWASAKI Hirokazu

  Department of Pharmacology, Gifu Pharmaceutical University

• Kawasaki Hirokazu

  岐阜薬科大学 薬理

• Kawasaki Hirokazu

  Department Of Pharmacology Gifu Pharmaceutical University

• Kimata Masahiro

  岐阜薬科大学 薬理学

• Inagaki N

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Inagaki Naoki

  Department Of Electrical And Computer Engineering Nagoya Institute Of Technology

• Inagaki Naoki

  Department Of Pharmacology Gifu Pharmaceutical University

• Kimata Masahiro

  Department Of Pharmacology Gifu Pharmaceutical University

• Nagai Hiroichi

  Department Of Clinical Pharmacology Gifu Pharmaceutical University

• Nakamura Nobuaki

  岐阜薬科大学 薬理

• Nakai Noriko

  岐阜薬科大学薬理学教室

• Kimata Masahiro

  Department Of Clinical Pharmacy Gifu Pharmaceutical University

• Nakai Noriko

  Department Of Pharmacology Gifu Pharmaceutical University

• Miura Katsuhiro

  Department Of Pharmacology Gifu Pharmaceutical University

• Inagaki Naoki

  Departmen T Of Pharmacology Gifu Pharmaceutical University

• Inagaki Naoki

  Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Information Science Gifu University

• Nagai Hiroichi

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama

• KAWASAKI Hirokazu

  Department of Hospital Pharmacy

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