Studies on the Anti-allergic Mechanism of Glucocorticoids in Mice
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概要
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Glucocorticoids inhibit IgE antibody-mediated passive cutaneous anaphylaxis (PCA) and chemical mediator-induced cutaneous reactions elicited in the mouse ear. In the present study, we investigated the effect of actinomycin D, a protein synthesis inhibitor, on dexamethasone-caused inhibition of PCA and histamine-induced cutaneous reaction in the mouse ear. Tyrosine aminotransferase (TAT) activity in the liver, which was estimated as an index for protein synthesis, significantly increased by the administration of hydrocortisone, prednisolone and dexamethasone. Significant increase in TAT activity was observed from 2h after glucocorticoid administration and peaked at 4h, and declined gradually thereafter. Cycloheximide even at high doses of 100 and 300 mg/kg failed to affect the increase in TAT activity by dexamethasone. On the contrary, actinomycin D at doses of 1 and 10 mg/kg abrogated the TAT activity increase by dexamethasone almost completely. Treatment with 1 mg/kg of actinomycin D, however, failed to affect the inhibition of PCA and histamine-induced cutaneous reaction by dexamethasone. These results suggest that glucocorticoids exhibit their inhibitory action of PCA and chemical mediator-induced cutaneous reactions in mice through a mechanism resistant to actinomycin D treatment.
- 公益社団法人日本薬学会の論文
著者
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YOSHIDA Kenji
Department of Electronic Information Systems, Shibaura Institute of Technology
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Miura T
Pharmaceutical Development Laboratory And Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Miura Toru
Department of Biology, Graduate School of Arts and Sciences, University of Tokyo
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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Koda Akihide
岐阜薬科大学 薬
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Inagaki N
Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University
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NAKAJIMA Takashi
Department of Urology, Kawasaki Medical School
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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KODA AKIHIDE
Department of Pharmacology, Gifu College of Pharmacy
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Miura Toru
Pharmaceutical Development Laboratory And Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Matsuyama Toshifumi
Pharmaceutical Development Laboratory And Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Nakajima Takashi
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Yoshida K
Tokyo Inst. Technol. Yokohama Jpn
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Miura Toru
Department Of Biology Graduate School Of Arts And Sciences University Of Tokyo
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Nakajima Takashi
Department Network And Computer Engineering School Of Information And Design Engineering Tokai Unive
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Miura Toru
Pharmaceutical Research Laboratory Kirin Brewery Company Limited
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Yoshida Kenji
Department Of Chemistry Faculty Of Science Ehime University
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Inagaki Naoki
Immunopharmacology Field Of Biofunctional Control Medical Information Science Division United Graduate School Of Drug Discovery And Medical Information Sciences Gifu University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Yoshida Kenji
Department of Biochemistry, Kinki University School of Medicine
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