SPECIFIC SUPPRESSION OF ANTIGEN-ANTIBODY REACTIONS BY A DIALYSATE FROM DERMATOPHAGOIDES FARINAE
スポンサーリンク
概要
- 論文の詳細を見る
Mite dialysate prepared from an extract of house dust mite, Dermatophagoides farinae, suppressed 48-h homologous passive cutaneous anaphylaxis (PCA) in rats caused by a non-dialyzable fraction of the mite extract (mite antigen), and the suppression was dosedependent with a high specificity for the antigen. The mite dialysate itself slightly elicited the PCA. Fraction 3 obtained from the mite dialysate by means of DEAE-Sephadex A-25 column chromatography suppressed PCA in rats and guinea pigs more potently than mite dialysate. Histamine release from sensitized rat peritoneal exudate cells (PEC) induced by the mite antigen was suppressed in a dose-dependent manner when the PEC had been previously incubated with fraction 3. However, incubation of the PEC with fraction 3 caused a significant release of histamine compared to the spontaneous value. Fraction 3 clearly inhibited the passive hemagglutination of the mite antigen-conjugated sheep red blood cells caused by rat hyperimmunized serum. From these results it was considered that certain haptenic substances might be present in the mite dialysate.
- 公益社団法人日本薬学会の論文
著者
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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Koda Akihide
岐阜薬科大学 薬
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Tsuruoka N
Laboratory For Health Care Science Research Center Suntory Ltd.
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KODA AKIHIDE
Department of Pharmacology, Gifu College of Pharmacy
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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TSURUOKA NOBUO
Department of Pharmacology, Gifu Pharmaceutical University
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DAIKOKU MICHIO
Department of Pharmacology, Gifu Pharmaceutical University
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YAGI AKIRA
Department of Pharmacology, Gifu Pharmaceutical University
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NISHIOKA ITSUO
Department of Pharmacology, Gifu Pharmaceutical University
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Nishioka Itsuo
Department Of Forestry Faculty Of Agriculture Kyushu University
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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YAGI Akira
Department of Pharmacognosy, Faculty of Kyushu University
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