The Effect of TRK-530 on Experimental Arthritis in Mice
スポンサーリンク
概要
- 論文の詳細を見る
TRK-530 is a newly synthesized diphosphonate derivative. We investigated the effect of TRK-530 on type II collagen-induced arthritis (CIA) in mice in comparison to that of prednisolone and indomethacin. TRK-530 at a dose of 25 mg/kg showed a tendency to inhibit CIA. TRK-530 at a dose of 50 mg/kg inhibited the development of the CIA in terms of the progression of footpad swelling, bone damage and histopathological changes. TRK-530 at a dose of 50 mg/kg also significantly inhibited the delayed type hypersensitivity (DTH) response to type II collagen, but not the production of anti-type II collagen IgG antibody in arthritic mice.To investigate the inhibitory mechanism of TRK-530,the type of effect of TRK-530 on the production of IL-1β in vitro was studied. TRK-530 at a concentration of 10^<-4>M inhibited LPS-induced IL-1β production from J774.1 cells.In conclusion, TRK-530 inhibited CIA in mice. The inhibition of the DTH reaction to type II collagen and the inhibition of IL-1β production may partly participate the anti-rheumatoid action of TRK-530.
- 公益社団法人日本薬学会の論文
- 1997-11-15
著者
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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TAKAOKA Yuko
Department of Pharmacology, Gifu Pharmaceutical University
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MORI Hiroshi
Department of Pharmacology, Gifu Pharmaceutical University
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Mori Hiroshi
Department Of Architecture Graduate School Of Engineering Nagoya University
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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TANAHASHI Masahiko
Toray Industries, Inc., Basic Research Laboratories
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Takaoka Yuko
Department Of Pharmacology Gifu Pharmaceutical University
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Mori Hiroshi
Department Of Applied Physics Okayama University Of Science
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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