Active Principle of Swine Prostate Extract:I. Isolation of Active Principle Activating Prostatic Acid Phosphatase and Its Effect on Testosterone Uptake of the Prostate in Castrated Rats.
スポンサーリンク
概要
- 論文の詳細を見る
There have been several reports concerning the therapeutic effect of an extract from animal prostates on benign prostatic hypertrophy. Previously, we reported that the swine prostate extract (PE) had the activity to enhance human prostatic acid phosphatase (PAPase) activity in vitro, and to increase the muscular tonicity of the urinary bladder by directly acting upon vesical muscles, suggesting that PE have an activity to elevate the intravesical voiding pressure in vivo. In the present study, it was attempted to isolate such an active principle of PE as activates human prostatic acid phosphatase (PAPase). The finally purified PE (PPE) was assessed as to some physico-chemical and pharmacological properties. 1) PPE was found to be a peptide with a molecular weight of about 8, 800, composed largely of neutral amino acids (approximately 70%) and few of aromatic amino acids. 2) PPE activated PAPase in a dose-dependent fashion, resulting in an increase of the enzyme activity approximately twice in a dose of 2 × 10<SUP>-5</SUP> g/ml of PPE. Furthermore, PPE recovered PAPase activity dose-dependently from the 50% inhibition by 2 × 10<SUP>-3</SUP> M L-tartaric acid. 3) In castrated rats, the <SUP>3</SUP>H-testosterone uptake of the prostate was significantly suppressed by the oral administration of PPE. PPE might be one of active principles of PE for the therapeutic effect on prostatic hypertrophy.
- 公益社団法人 日本薬理学会の論文
著者
-
MORI Hiroshi
Department of Pharmacology, Gifu Pharmaceutical University
-
Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
-
Yoshida Yoichi
Research And Development Headquarters Of Ubekousan
-
Mori Hiroshi
Department Of Applied Physics Okayama University Of Science
-
Yoshida Yoichi
Research Laboratory , Nippon Shoji Kaisha, Ltd.
-
Inami Kanji
Department of Pharmacology, Gifu Pharmaceutical University
関連論文
- <Symposium IV>Oligomeric Aβ is the sole culprit molecule to cause Alzheimer's disease?
- Effect of Mizoribine on Effector T Cell-Mediated Immune Responses in Mice
- Terbutaline-Induced Triphasic Changes in Volume of Rat Alveolar Type II Cells:The Role of cAMP
- Correlation between the temperature of molten state and the SH intensity of 30BaO・15TiO_2・55GeO_2 crystallized glass
- SIMULATION OF CONSISTENCY TESTS FOR HIGH-FLUIDITY CONCRETE BY VISCOPLASTIC DIVIDED SPACE ELEMENT METHOD
- EXPERIMENTAL AND ANALYTICAL STUDIES ON PROPAGATION OF VIBRATION IN FRESH CONCRETE
- MICROSCOPIC STUDY ON VISCO-ELASTIC LIMIT OF CEMENTITIOUS MATERIALS
- STUDY ON INFLUENCE OF VARIOUS ADDITIVES ON SEGREGATION RESISTIVITY OF FRESH CONCRETE
- A STUDY ON EFFECT OF SUPERFINE POWDERS ON FLUIDITY OF CEMENT PASTE
- ANALYTICAL STUDY ON VIBRATION TRANSMISSION PROPERTIES OF FRESH CONCRETE
- STUDY ON CASTING OF HIGH-FLUIDITY CONCRETE INTO MIDDLE-SIZE WALL FORMS
- FUNDAMENTAL STUDY ON FLOWING PROCESS OF MAIRIX MORTAR BASED ON FILTRATION THEORY
- MODEL ANALYSIS ON EFFECT OF MICRO PARTICLE ON FAILURE PROPERTIES OF CONCRETE
- ANALYTICAL STUDY ON DYNAMIC PROPERTIES OF CONCRETE UNDER HIGH-SPEED COMPRESSIVE LOADING
- FLOW SIMULATION OF FRESH CONCRETE CAST INTO WALL STRUCTURE BY VISCOPLASTIC DIVIDED SPACE ELEMENT METHOD
- EXPERIMENTAL STUDY ON ADHESIVE AND HIGH SPEED SLIPPING PROPERTIES OF VISCOPLASTIC MATERIALS
- FUNDAMENTAL STUDY ON SEGREGATION RESISTIVITY OF FRESH CONCRETE
- ANALYTICAL STUDY ON TENSILE AND BENDING FAILURES OF CONCRETE BY VISCO-ELASTO-PLASTIC SUSPENSION ELEMENT METHOD
- 222. Experimental Study on Drug-induced Contact Dermatitis as a Model Using p-Phenylendiamine (The Second Meeting for the Study of Toxic Effect)
- Studies on Anti-allergic Action of AH 21-132, a Novel Isozyme-Selective Phosphodiesterase Inhibitor in Airways
- Autopsy case of lymphoplasmacytic lymphoma with a large submucosal tumor in the stomach
- Ultrastructural study on cytotoxic effects of cyclosporine A in spermiogenesis in rats
- Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome
- Chordoma in the Sella Turcica
- Tau protein is a potential biological marker for normal pressure hydrocephalus
- Lipomatous pleomorphic adenoma of the ceruminous gland
- IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
- Synovial sarcoma arising from the pleura : a case report with ultrastructural and immunohistological studies
- Pharmacological Study of Phospholipase A_2-Induced Histamine Release from Rat Peritoneal Mast Cells
- Extracerebral ectopic mass with huge cysts in the anterior cranial cavity
- Symptomatic Child Case of Subependymoma in the Fourth Ventricle without Hydrocephalus
- Evaluation of Anti-allergic Effects of 1-Substituted 2-n-Butyl-methylenedioxy Indenes
- Effects of ACNU and Cranial Irradiation on the Mouse Immune System
- Duct-acinar-islet cell tumor of the pancreas
- Clinical Findings in Japanese Patients with Waardenburg Syndrome Type 2
- Visual Evoked Potentials Elicited by Pseudorandom Stimulation from Patients with Macular Degeneration
- Endometrial Cancer of the Uterus in a Patient with Spinal Cord Injury
- Restoration of Leydig cells after repeated administration of ethane dimethanesulfonate in adult rats
- The Syntaxin 5 Isoforms Syx5 and Syx5L have Distinct Effects on the Processing of β-amyloid Precursor Protein
- Studies on the Anti-allergic Mechanism of Glucocorticoids in Mice
- Anaplastic large-cell lymphoma (Ki-1 lymphoma) : ultrastructural and immunohistochemical studies
- Case of primary malignant hemangiopericytoma of the heart expressing basement membrane-degradable enzymes
- Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinase, collagens, and Ki67 antigen in pleural malignant mesothelioma : an immunohistochemical and electron microscopic study
- Increased exocytosis of secretory granules in contrast to reduced serum hormone levels in pituitary adenomas of humans and rats treated with dopamine agonist
- SPECIFIC SUPPRESSION OF ANTIGEN-ANTIBODY REACTIONS BY A DIALYSATE FROM DERMATOPHAGOIDES FARINAE
- IMMUNOGLOBULIN E ANTIBODY PRODUCTION AGAINST HOUSE DUST MITE, DERMATOPHAGOIDES FRARINAE, IN MICE
- Congenital mediastinal bronchogenic cyst with malignant transformation : An autopsy report
- Effect of CV-3988,a Specific Antagonist against Platelet Activating Factor, on Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- Thermal,Electrical and Magnetic Properties of the Ferromagnetic Dense Kondo System CeSi_x
- Expression of thrombomodulin in human aortic smooth muscle cells with special reference to atherosclerotic lesion types and age differences
- Radiation-induced Diffuse Brain Injury in the Neonatal Rat Model : Radiation-induced Apoptosis of Oligodendrocytes
- The Immunotoxicity of Triphenyltin Chloride in Mice
- The Effect of TRK-530 on Experimental Arthritis in Mice
- Primary hepatic leiomyosarcoma in a patient with hepatitis C virus-related liver cirrhosis
- Suppressive Effects of Tranilast on Pulmonary Fibrosis and Activation of Alveolar Macrophages in Mice Treated with Bleomycin: Role of Alveolar Macrophages in the Fibrosis
- ANALYSIS OF COMPRESSIVE FRACTURE OF CONCRETE BY VISCO-ELASTO-PLASTIC SUSPENSION ELEMENT METHOD USING DELAUNAY TRIANGULATION
- STUDY ON EFFECT OF VOLUME FRACTION OF COARSE AGGREGATE ON COMPRESSIVE FAILRE OF CONCRETE
- STUDY ON EFFECTS OF SIZE AND ARRANGEMENT OF COARSE AGGREGATE ON COMPRESSIVE FRACTURE BEHAVIOR OF CONCRETE
- EXPERIMENTAL STUDY ON PASSING BEHAVIOR OF FRESH CONCRETE BETWEEN STEEL BARS BY VISUALIZED MODEL CONCRETE
- Mitotic Specific Phosphorylation of Serine-1212 in Human DNA Topoisomerase IIα
- Effect of Tranilast on Endothelin-Induced Bronchoconstriction in Guinea Pigs
- Effect of a Non-Protein Fraction from an Extract of the Inflamed Skin of Rabbits Inoculated with Vaccinia Virus (Neurotropin) on Meth A-Induced Delayed Type Hypersensitivity
- The effects of TYB-2285 and its metabolites on eosinophil adhesion to tumor necrosis factor α-stimulated human umbilical vein endothelial cells
- EFFECT OF 1, 3-BIS (2-PHENYL-4-CHROMENON-5-YL)-2-OL ON EXPERIMENTAL ASTHMA IN GUINEA PIGS
- HISTAMINE RELEASE FROM RAT NEUTROPHILS AND MAST CELLS AS INDUCED BY IONOPHORE —A PHARMACOLOGICAL APPROACH—
- High Yield Synthesis of 12-Aminolauric Acid by "Enzymatic Transcrystallization" of ω-Laurolactam Using ω-Laurolactam Hydrolase from Acidovorax sp. T31
- INHIBITION OF HOMOLOGOUS PASSIVE CUTANEOUS ANAPHYLAXIS (PCA) BY DISODIUM CROMOGLYCATE-RELATED COMPOUNDS
- PHARMACOLOGICAL STUDIES ON THE RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS DURING ANTI-IMMUNOGLOBULIN E ANTIBODY MEDIATED PASSIVE PERITONEAL ANAPHYLAXIS IN RATS
- EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS
- Comparative Study of 1.5-Hour and 48-Hour Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- The Effect of Substance P on the Antigen-Induced Bronchoconstriction in Guinea Pigs
- A COMPARATIVE STUDY OF THE ANTI-ALLERGIC EFFECTS OF DISODIUM BAICALEIN 6-PHOSPHATE (BPS) AND DISODIUM CROMOGLYCATE (DSCG)
- STUDIES ON THE MECHANISMS OF THE INHIBITORY EFFECT OF N-5 ON HISTAMINE RELEASE FROM RAT PERITONEAL EXUDATE CELLS
- THE SUSCEPTIBILITY OF EXPERIMENTAL GLOMERULONEPHRITIS IN SIX DIFFERENT STRAINS OF MICE
- ANTI-TUMOR EFFECT OF NEW 5-FLUOROURACIL DERIVATIVES AND THEIR INFLUENCES ON THE IMMUNE RESPONSE
- Antitumor Activity of Two Novel Low Immunosuppressive Fluoropyrimidines UK-21 and UK-25.
- Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-.BETA.-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-(1,5-a) pyridine (KC-404).
- Experimental glomerulonephritis in mice as a model for immunopharmacological studies.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.
- Anti-allergic action of glucocorticoids in rats.
- Mechanisms of antiumor activity of aqueous extracts from chinese herbs: Their imunopharmacological properties.
- Active Principle of Swine Prostate Extract: II. Effect of a Peptide Isolated from Swine Prostate Extract on Rat Prostate.
- Potent inhibitory activity of HSR-6071, a new antiallergic agent, on Passive Cutaneous Anaphylaxis(PCA).
- Active Principle of Swine Prostate Extract:I. Isolation of Active Principle Activating Prostatic Acid Phosphatase and Its Effect on Testosterone Uptake of the Prostate in Castrated Rats.
- The effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice.
- Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.
- Inhibition of IgE antibody formation by n-pentyl .ALPHA.-L-sorbopyranoside.
- Mechanisms for Glucocorticoid Inhibition of Immediate Hypersensitivity Reactions in Rats.
- INHIBITION OF HYPERSENSITIVITY REACTIONS BY SOLUBLE DERIVATIVES OF BAICALEIN
- Change in the activity of the cyclic AMP-dependent protein kinase in antigen-stimulated sensitized mast cells and effect of drugs inhibiting allergic mediator release.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2). Regulation of Human IgE Response.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (1). Regulation of Murine IgE Response.
- Effects of MKS-492 on Antigen-Induced Bronchoconstriction and Allergic Reaction in Guinea Pigs and Rats.
- Effect of N-5' on histamine release from rat peritoneal exudate cells induced by calcium ionophore and ATP.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis.
- Liver injury model in mice for immunopharmacological study.
- Effect of Three Novel K+ Channel Openers, Cromakalim, Pinacidil and Nicorandil on Allergic Reaction and Experimental Asthma.
- Immunological mechanisms of antitumor activity of some kinds of Chinese herbs: meth A-induced delayed type hypersensitivity.
- Effect of OKY-046 and ONO-3708 on liver injury in mice.
- Immunopharmacological studies of sodium copper chlorphyllin (SCC).