Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2). Regulation of Human IgE Response.

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概要

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• The ability of IPD-1151T to suppress the induction of human IgE synthesis was investigated with an in vitro model of IgE production mediated by an allergen-specific helper T cell line (SN-4)from a patient allergic to Japanese cedar pollen. IPD-1151T induced a concentration-dependent suppression of purified allergen (<I>Cry j</I> 1)-dependent IgE synthesis in autologous B cell cultures mediated by SN-4, without significantly affecting the IgG synthesis. In addition, the production of interleukin 4 (IL-4)by <I>Cry j 1</I>-activated SN-4 as well as that by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC)of normal donors was inhibited in a concentration-dependent manner by the agent. Interestingly, IPD-1151T clearly depressed PHA-induced expression of IL-4 mRNA in normal PBMC, indicating that this agent inhibits IL-4 gene transcription. However, IPD-1151T had no antagonistic action on IL-4, since neither IL-4-induced expression of low-affinity IgE receptor (Fc ε RII/CD23)on normal B cells nor soluble Fc e RII release from IL-4-stimulated B cells was affected by the agent. On the other hand, IPD-1151T had no effect on the production of interferon-γ by both <I>Cry j</I> 1-stimulated SN-4 and anti-CD3 monoclonal antibody-activated T cells of normal donors. These results suggest that the selective suppression of IgE synthesis by IPD-1151T results from the inhibition of IL-4 production by T cells at the gene level.

• 公益社団法人 日本薬理学会の論文

著者

• Ikizawa Koichi

  Clinical Research Center For Allergy National Sagamihara Hospital

• MATSUURA NAOSUKE

  Department of Pharmacology, Gifu College of Pharmacy

• Koda Akihide

  Department Of Pharmacology Gifu College Of Pharmacy

• Yanagihara Yukiyoshi

  Clinical Research Center For Allergy And Rheumatology National Hospital Organization Sagamihara Nati

• SHIDA Takao

  Clinical Research Center for Allergy, National Sagamihara Hospital

• Kiniwa Mamoru

  Clinical Research Center for Allergy, National Sagamihara Hospital

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