Effect of butyl 3-(1H-tetrazol-5-yl) oxanilate(MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the influence of butyl 3-(1 H-tetrazol-5-yl) oxanilate (MTB) on the release of histamine and slow reacting substance of anaphylaxis (SRS-A) in vitro. MTB dose-dependently inhibited the release of not only histamine but also SRS-A from passively sensitized guinea-pig lung, while disodium cromoglycate (DSCG) hardly affected either release. MTB also resulted in a dose-dependent inhibition of the release of these mediators from the passively sensitized cynomolgus and rhesus monkey and that from human lung at concentrations similar to those inhibiting the release in the guinea-pig. Relatively lower inhibitory activities on the releases of both mediators from the cynomolgus monkey and human lung, but no effects on those from the rhesus monkey were observed with DSCG. MTB dose-dependently inhibited only SRS release from guinea-pig lung induced by phospholipase A<SUB>2</SUB>, although the compound did not show any inhibitory activity on the release of those from the calcium ionophore (A23187)-stimulated one. On the other hand, the release of SRS, but not that of histamine from the lung stimulated with A23187 as well as phospholipase A<SUB>2</SUB> was inhibited by N-(3, 4-dimethoxycinnamoyl)-anthranilic acid (tranilast, N-5'). From these results, MTB was a potent inhibitor of the anaphylactic release of the mediators, particularly SRS-A. It was suggested that the inhibitory mechanism of MTB is different from those of DSCG and N-5'.
- 公益社団法人 日本薬理学会の論文
著者
-
Ohata Katsuya
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
-
Yanagihara Yukiyoshi
Clinical Research Center For Allergy And Rheumatology National Hospital Organization Sagamihara Nati
-
Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
-
Hashimoto Terumasa
Department Of Pharmacology School Of Pharmacy Shawa University
-
SHIDA Takao
Clinical Research Center for Allergy, National Sagamihara Hospital
関連論文
- Inhibition of Anaphylactic Chemical Mediator Release by Tranilast.
- Seroprevalence of Antibodies to Chlamydia spp.in Human Immunodeficiency Virus-Infected Subjects in Japan
- Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells
- Induction of IgE synthesis by genetically modified CD8+ T cells of a patient with adenosine deaminase deficiency
- Reproducible Biphasic Cutaneous Edema Induced by Topical and Repeated Application of Antigen in Sensitized Mice
- Comparative studies on nebulizers fro antigen inhalation in experimental asthma
- A New Model of Experimental Allergic Rhinitis Using Japanese Cedar Pollen in Guinea Pigs
- Repeated Antigen Inhalation-Induced Reproducible Early and Late Asthma in Guinea Pigs
- Sephadex G-200-Induced Eosinophil Infiltration into Airways in Non-sensitized and Sensitized Guinea Pigs, and Responsiveness of the Calls to Stimuli In Vitro
- Antiallergic Effects of Mequitazine. II. : In Vivo Experiments.
- Antiallergic Effects of Mequitazine. I. : In Vitro Experiments.
- Delayed Type Allergic Itch-Associated Response Induced by Toluene-2,4-diisocyanate in Hairless Mice
- Differential regulation of thymus- and activation-regulated chemokine induced by IL-4, IL-13, TNF-α and IFN-γ in human keratinocyte and fibroblast
- Blocking the CD154-CD40 interaction with anti-CD154 antibody differntially regulates interleukin-4 synthesis in T cells and IgE production in B cells
- Molecular regulation of human IgE synthesis
- Recombinant soluble form of the high-affinity IgE receptor α subunit and anti-IgE antibody inhibit IgE synthesis by IgE-expressing B cells through distinct pathways
- Role of Rho-Associated Protein Kinase and Histamine in Lysophosphatidic Acid-Induced Airway Hyperresponsiveness in Guinea Pigs
- Markedly Increased Nasal Blockage by Intranasal Leukotriene D_4 in an Experimental Allergic Rhinitis Model: Contribution of Dilated Mucosal Blood Vessels
- IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
- Pulmonary Emphysema Induced by Cigarette Smoke Solution and Lipopolysaccharide in Guinea Pigs
- Absence of Nasal Blockage in a Japanese Cedar Pollen-Induced Allergic Rhinitis Model Mouse
- Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs
- Effects of Multiple Dexamethasone Treatments on Aggravation of Allergic Conjunctivitis Associated with Mast Cell Hyperplasia(Pharmacology)
- Polycyclic Aromatic Hydrocarbons Aggravate Antigen-Induced Nasal Blockage in Experimental Allergic Rhinitis
- Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis
- Development of Numerous Nerve Fibers in the Epidermis of Hairless Mice With Atopic Dermatitis-Like Pruritic Skin Inflammation
- Detection of New Antigenic Proteins in Japanese Cedar Pollen(Pharmacology)
- Effect of Oral Immunotherapy on Nasal Blockage in Experimental Allergic Rhinitis
- Acquired Nasal Hyperresponsiveness Aggravates Antigen-Induced Rhinitis in the Guinea Pig
- Multiple Cedar Pollen Challenge Diminishes Involvement of Histamine in Allergic Conjunctivitis of Guinea Pigs (Highlighted paper selected by Editor-in-chief)(Pharmacology)
- Comparison of Cedar Pollen - Induced Allergic Rhinitis in Passively and Actively Sensitized Guinea Pigs
- A Tiaramide Derivative, 5-Chloro-3-(4-hydroxypiperadinocarbonylmethyl) benzothiazoline-2-one (HPR-611), a Potent Inhibitor of Anaphylactic Chemical Mediator Release-A Distinctive Feature from Disodium Cromoglycate
- Expression and Function of the Inducible Costimulator Ligand B7-H2 in Human Airway Smooth Muscle Cells
- Comparative Study of Calcium Ion Dynamics and Contractile Response in Rat Middle Cerebral and Basilar Arteries
- Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
- Lysophosphatidic Acid Enhances In Vivo Infiltration and Activation of Guinea Pig Eosinophils and Neutrophils via a Rho/Rho-Associated Protein Kinase-Mediated Pathway
- EFFECTS OF INTRAVENTRICULARLY ADMINISTERED SEROTONIN, NORADRENALINE, DOPAMINE AND METARAMINOL ON THE RESERPINE-INDUCED SPIKES RECORDED FROM THE MEDIAL NUCLEUS TRAPEZOIDES IN RABBITS
- Atopic dermatitis model of itching behavior in hairless mice
- Repeated Antigen Inhalations Alter Chemical Mediators That Cause Asthmatic Obstruction in Guinea Pigs
- PHARMACOLOGICAL ACTIVITIES OF A KININ RELEASED FROM RAT PLASMA BY CATHEPTIC ENZYME IN RAT STOMACH
- KININ FORMATION BY CATHEPTIC ENZYME IN RAT STOMACH
- A NEW BIOLOGICAL BRADYKININ-LIKE PEPTIDE IN RAT STOMACH
- EXISTENCE OF A BRADYKININ-LIKE SUBSTANCE, AND INFLUENCE OF CARBACHOL AND ATROPINE ON KININ-FORMING AND DESTROYING ACTIVITIES, AND KININ AND KININOGEN CONTENTS IN RAT STOMACH
- A BRADYKININ-LIKE SUBSTANCE IN RAT STOMACH
- STUDIES ON KININ-FORMING ENZYME IN RAT STOMACH
- PROPERTY OF KININ-FORMING ENZYME IN RAT STOMACH
- Arachidonate 5-Lipoxygenase and Cyclooxygenase Metabolites From Guinea Pig Eosinophils and Macrophages
- Effect of a Hydrolysate from Human Placenta on Baby Hamster Kidney-21 Cell
- A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite
- Inhibitory Effect of Chitosan-Containing Lotion on Scratching Response of Hairless Mice with Atopic Dermatitis-Like Dry Skin
- Effect of AS-35 on Agonist-Induced Contractions and the Resting Tonus of Airway Smooth Muscles and the In Vitro Release of Chemical Mediators from Passively Sensitized Lung Fragments from Humans and Guinea Pigs.
- Immunopharmacological studies on TBX, a new antiallergic drug. (4). Effects on type II to IV allergic reactions and immunological functions in animal models.
- Immunopharmacological studies on TBX, a new antiallergic drug. (2) inhibitory effects on histamine release from peritoneal mast cells and lung fragments of rats.
- Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.
- Effect of oxitropium bromide (Ba253) on increased airway resistance induced by various agonists and antigen in the guinea pig.
- Possible Participation of Histamine H3-Receptors in the Regulation of Anaphylactic Histamine Release from Isolated Rat Peritoneal Mast Cells.
- Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
- Dimaprit, a Histamine H2-Agonist, Inhibits Anaphylactic Histamine Release from Mast Cells and the Decreased Release Is Restored by Thioperamide (H3-Antagonist), but Not by Cimetidine (H2-Antagonist).
- Significant Role of Peptide Leukotrienes (p-LTs) in the Antigen-Induced Contractions of Human and Guinea Pig Lung Parenchymas and Bronchi or Tracheas In Vitro.
- Two-Phase Increment of Ca2+ Uptake, Intracellular Ca2+ Concentration, and Histamine Release Following Antigen Stimulation in Mouse Bone Marrow-Derived Mast Cells (BMMC).
- Important Role of Peptide Leukotrienes (p-LTs) in the Resting Tonus of Isolated Human Bronchi.
- Inhibition of Radiolabeled Leukotriene-Binding by AS-35 in Guinea Pig Lung Membrane Fraction.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2). Regulation of Human IgE Response.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (1). Regulation of Murine IgE Response.
- Effect of oexitropium bromide (Ba253) on isolated respiratory smooth muscle and release of chemical mediators from passively sensitized lung fragments.
- Immunopharmacological studies on TBX, a new antiallergic drug. (1). Inhibitory effects on passive cutaneous anaphylaxis in rats and guinea pigs.
- Studies on toluene diisocyanate (TDI)-induced delayed type hypersensitivity.
- Immunopharmacological studies on TBX, a new antiallergic drug. (3). Inhibitory effects on histamine release from lung fragments and bronchoconstriction in guinea pigs.
- Receptor binding profile of quinupramine, a new tricyclic antidepressant.
- Peptide Leukotriene Antagonistic Activity of AS-35, a New Antiallergic Drug.
- Effect of butyl 3-(1H-tetrazol-5-yl) oxanilate(MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.
- Binding characteristics of (3H)quinupramine to rat brain membrane fractions.
- MCI-826 Is a Potent and Selective Antagonist of Peptide Leukotrienes(p-LTs) and Has Characteristics Distinctive from Those of FPL 55712.