Immunopharmacological studies on TBX, a new antiallergic drug. (1). Inhibitory effects on passive cutaneous anaphylaxis in rats and guinea pigs.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1, 2-a]pyrimidin-4-one potassium salt (TBX), a new antiallergic drug, on passive cutaneous anaphylaxis (PCA) mediated by homologous IgE or IgG antibody were investigated in rats and guinea pigs. TBX (i.v. and p.o.) clearly inhibited IgE- and IgG<SUB>a</SUB>-mediated homologous PCAs in rats, without showing any inhibition of the skin reactions caused by histamine, serotonin and bradykinin in contrast to the inhibition of prostaglandin E<SUB>1</SUB>-induced skin reaction. Neither adrenalectomy nor propranolol treatment modified TBX's inhibition of the former PCA. With regard to tachyphylaxis to TBX, it was demonstrable in IgE-mediated homologous PCA in rats when they were pretreated with TBX (0.5 mg/kg, i.v.), followed 60 min later by a second dose of the drug (0.05 mg/kg, i.v.). There was no cross-tachyphylaxis between disodium cromoglycate (DSCG) and TBX. Homologous PCA caused by guinea pig IgE was also inhibited in a dose-dependent fashion by i.v. and p.o. administrations of TBX, although higher doses of TBX were needed to inhibit guinea pig PCA than the rat one. Interestingly, TBX showed more potent inhibition of both rat and guinea pig homologous PCAs than DSCG or tranilast. The results obtained indicate that TBX is an orally effective antiallergic agent displaying no antagonistic actions on the chemical mediators released.
- 公益社団法人 日本薬理学会の論文
著者
-
Yanagihara Yukiyoshi
Clinical Research Center For Allergy And Rheumatology National Hospital Organization Sagamihara Nati
-
KASAI Hiroshi
Research Laboratories, Tokyo Tanabe Pharmaceutical Co., Ltd.
-
KAWASHIMA Toshio
Research Laboratories, Tokyo Tanabe Pharmaceutical Co., Ltd.
-
SHIDA Takao
Clinical Research Center for Allergy, National Sagamihara Hospital
関連論文
- Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells
- Induction of IgE synthesis by genetically modified CD8+ T cells of a patient with adenosine deaminase deficiency
- Differential regulation of thymus- and activation-regulated chemokine induced by IL-4, IL-13, TNF-α and IFN-γ in human keratinocyte and fibroblast
- Blocking the CD154-CD40 interaction with anti-CD154 antibody differntially regulates interleukin-4 synthesis in T cells and IgE production in B cells
- Molecular regulation of human IgE synthesis
- Recombinant soluble form of the high-affinity IgE receptor α subunit and anti-IgE antibody inhibit IgE synthesis by IgE-expressing B cells through distinct pathways
- Expression and Function of the Inducible Costimulator Ligand B7-H2 in Human Airway Smooth Muscle Cells
- Effect of a Hydrolysate from Human Placenta on Baby Hamster Kidney-21 Cell
- Immunopharmacological studies on TBX, a new antiallergic drug. (4). Effects on type II to IV allergic reactions and immunological functions in animal models.
- Immunopharmacological studies on TBX, a new antiallergic drug. (2) inhibitory effects on histamine release from peritoneal mast cells and lung fragments of rats.
- Inhibition of Radiolabeled Leukotriene-Binding by AS-35 in Guinea Pig Lung Membrane Fraction.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2). Regulation of Human IgE Response.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (1). Regulation of Murine IgE Response.
- Immunopharmacological studies on TBX, a new antiallergic drug. (1). Inhibitory effects on passive cutaneous anaphylaxis in rats and guinea pigs.
- Immunopharmacological studies on TBX, a new antiallergic drug. (3). Inhibitory effects on histamine release from lung fragments and bronchoconstriction in guinea pigs.
- Peptide Leukotriene Antagonistic Activity of AS-35, a New Antiallergic Drug.
- Effect of butyl 3-(1H-tetrazol-5-yl) oxanilate(MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.