Immunopharmacological studies on TBX, a new antiallergic drug. (4). Effects on type II to IV allergic reactions and immunological functions in animal models.
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概要
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The effects of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1, 2-a]pyrimidin-4-one potassium salt (TBX) on type II to IV allergic reactions and immunological functions were investigated in animal models. Types II to IV allergic reactions in rodents were unaffected in vivo by TBX, even at higher doses than those capable of completely inhibiting the type I allergic reaction. However, both complement-mediated hemolysis via the classical pathway and hypotonic shock-induced hemolysis were slightly inhibited in vitro only by a high concentration of the drug (10<SUP>-4</SUP> g/ml). In the mouse system, TBX had no ability to suppress anti-hapten IgE anti-body formation as well as hemagglutinin formation and to inhibit the proliferation of spleen cells induced by non-specific T and B cell mitogens. The results obtained indicate that TBX is an antiallergic drug essentially devoid of inhibitory actions on types II to IV allergic reactions and immunological functions, thus indicating that it is a specific inhibitor of type I allergic reactions.
- 公益社団法人 日本薬理学会の論文
著者
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Yanagihara Yukiyoshi
Clinical Research Center For Allergy And Rheumatology National Hospital Organization Sagamihara Nati
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KASAI Hiroshi
Research Laboratories, Tokyo Tanabe Pharmaceutical Co., Ltd.
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KAWASHIMA Toshio
Research Laboratories, Tokyo Tanabe Pharmaceutical Co., Ltd.
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NINOMIYA Kenji
Research Laboratories, Tokyo Tanabe Pharmaceutical Co., Ltd.
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