Effect of Oral Immunotherapy on Nasal Blockage in Experimental Allergic Rhinitis
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概要
- 論文の詳細を見る
We previously reported that when Japanese cedar pollen was prophylactically p.o. administered before a sensitization stage in a guinea-pig model of allergic rhinitis, pollen-induced nasal blockage was suppressed. In this study, we evaluated whether the oral immunotherapy is also effective when the pollen extract was administered starting from the day when the nasal blockage was clearly induced and whether the effectiveness continued after cessation of the immunotherapy. Sensitized animals were repeatedly challenged by pollen inhalation once every week. After the 7th challenge, the extract was orally administered twice a week until the 30th challenge. At the 11th challenge, the oral immunotherapy showed inhibition of the biphasic nasal blockage. The effectiveness was consistently observed during the immunotherapy until the 30th challenge. Furthermore, the increased nasal responsiveness to intranasal application of leukotriene D4 was markedly suppressed by the immunotherapy. Interestingly, even after cessation of the therapy, inhibition of the nasal blockage was sustained for more than 2 months. Nevertheless, neither sneezing nor antigen-specific IgE antibody production was substantially influenced by the immunotherapy. In conclusion, Oral immunotherapy may be clinically useful for allergic nasal blockage. Mechanisms underlying the effectiveness may be associated with the hyporesponsiveness of the nasal mucosa to released mediators.
- 社団法人 日本薬理学会の論文
- 2005-08-20
著者
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TAKENAKA Hiroshi
Department of Earth and Planetary Sciences, Kyushu University
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Sugahara Yazuyuki
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Kubota Kayoko
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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NABE Takeshi
Department of Pharmacology, Kyoto Pharmaceutical University
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KOHNO Shigekatsu
Department of Pharmacology, Kyoto Pharmaceutical University
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TERADA Tetsuya
Department of Otorhinopharyngolaryngology, Osaka Medical College
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Terada Tetsuya
大阪医科大学 耳鼻咽喉科学
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Terada Tetsuya
Department Of Otorhinolaryngology Osaka Medical College
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Takenaka Hiroshi
Department Of Otolaryngology Osaka Medical College
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Takenaka Hiroshi
Department Of Otorhinolaryngology Osaka Medical College
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KUBOTA Kayoto
Department of Pharmacology, Kyoto Pharmaceutical University
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Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University:department Of Pneumology Ogaki Municipal
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Nabe Takeshi
Department Of Pharmacology Kyoto Pharmaceutical University
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Takenaka H
Kyushu Univ.
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Takenaka Hiroshi
Department Of Earth And Planetary Sciences Kyushu University
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Kubota Kayoko
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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Takenaka Hiroshi
Department Of Chemistry Faculty Of Science Osaka City University
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Nabe T
Department Of Pharmacology Kyoto Pharmaceutical University
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TERADA Tetsuya
Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences
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