IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
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概要
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The antagonistic effect of 2,4'-dimethyl-3-piperidino propiophenone hydrochloride (Mydocalm) and its 15 derivatives against the activity of slow reacing substance of anaphylaxis (SRS-A) were examined in vitro. Mydocalm, 2-methyl-3-piperidino-β-propionaphtone hydrochloride (As-5) and 2,3', 4'-trimethyl-3 piperidinopropiophenone hydrochloride (As-14) were found to be potent antagonists to SRS-A. The above three compounds inhibited homologous passive cutaneous anaphylaxis (PCA) in rats and guinea pigs but not heterologous PCA in guinea pigs. As-5 inhibited the release of histamine from and the degranulation of rat mesenterium mast cells. As-14 also showed the inhibition of the degranulation. Mydocalm, however, showed no inhibition of these reactions. Experimental asthma in guinea pigs which were passively sensitized with guinea pig immunoglobulin E antibody was significantly inhibited by p.o. adminstration of Mydocalm, As-5 or As-14 respectively.
- 公益社団法人日本薬学会の論文
著者
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Matsuura Naosuke
岐阜薬科大学 薬理
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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Koda A
Gifu Pharmaceutical Univ. Gifu Jpn
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SATO Natsuki
Department of Polymer Science and Engineering, Faculty of Engineering, Yamagata University
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Sato Natsuki
Department Of Pharmacology Gifu College Of Pharmacy
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KOHNO Shigekatsu
Department of Pharmacology, Kyoto Pharmaceutical University
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MATSUURA NAOSUKE
Department of Pharmacology, Gifu College of Pharmacy
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KODA AKIHIDE
Department of Pharmacology, Gifu College of Pharmacy
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Kohno Shigekatsu
Department Of Pharmacology Division Of Pathological Sciences Kyoto Pharmaceutical University
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Kohno Shigekatsu
Department Of Pharmacology Kyoto Pharmaceutical University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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SATO Natsuki
Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
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