The Effect of Mesoporphyrin on the Production of Cytokines by Inflammatory Cells In Vitro
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概要
- 論文の詳細を見る
This study was conducted to investigate a mechanism of the anti-inflammatory action of mesoporphyrin, especially the effect on the production of cytokines by some cultured inflammatory cells. Mesoporphyrin had no effect on lipopolysaccharide-induced tumor necrosis factor-α production by RAW 264.7 cells (murine macrophage-like cells). Mesoporphyrin inhibited interferon-γ production by 1E10.H2 cells (murine T helper-1 cells), but not interleukin-4 production by D10.G4.1 cells (murine T helper-2 cells). Mesoporphyrin inhibited interleukin-6 production by human osteoblast-like MG-63 cells. This inhibition of interleukin-6 production is closely related to the suppression of prostaglandin E2 generation by interfering cyclooxygenase 1 and 2 enzyme activities. These data suggest that the inhibition of cytokine production is one of the anti-inflammatory mechanisms of mesoporphyrin.
- 社団法人 日本薬理学会の論文
- 1999-05-01
著者
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Nagai H
Department Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
富山医科薬科大学和漢薬研究所
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Nii Hiroaki
岐阜薬科大学 薬理学
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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TAKAOKA Yuko
Department of Pharmacology, Gifu Pharmaceutical University
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Nojima Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Ohu University
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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MATSUURA Satoko
Department of Pharmacology, Gifu Pharmaceutical University
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BODA Keiko
Department of Pharmacology, Gifu Pharmaceutical University
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Takaoka Yuko
Department Of Pharmacology Gifu Pharmaceutical University
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Nojima Hiroshi
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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