Immunopharmacological Studies on Collagen-Induced Arthritis in Dark Agouti (DA) Rats
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概要
- 論文の詳細を見る
Dark Agouti (DA)and Lewis rat strains were tested for susceptibility to collagen-induced arthritis (CIA)and for development of cellular and humoral immune responses to type II collagen (CII). All of the DA rats developed arthritis following a single intradermal injection of more than 20 μg of CII (130-150 μg/kg rat weight)and showed a swelling rate of more than 100% in the hind paws. The swelling rate showed little deviation among the animals. There was a strong correlation between the severity of the arthritis and the strength of the immune response to CII in DA rats with CIA. Following immunization with even 800 μg of CII (3.8-4.2 mg/kg rat weight), Lewis rats showed a maximum rate of hind paw swelling of only 45%. In the pharmacological studies, prednisolone, indomethacin, FK-506 and mizoribine all suppressed arthritis in DA rats. These findings suggest that DA rats are more susceptible to CIA than Lewis rats and that CIA in DA rats as well as in Lewis rats is serviceable as an experimental animal model of rheumatoid arthritis.
- 社団法人 日本薬理学会の論文
- 1997-08-01
著者
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Nagai H
Department Of Pharmacology Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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KAMADA Hiroyuki
Department of Pharmacology, Gifu Pharmaceutical University
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TAKAOKA Yuko
Department of Pharmacology, Gifu Pharmaceutical University
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GOTO MORITAKA
Department of Medicine, Osaka Police Hospital
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Goto Moritaka
Department Of Medicine Osaka Police Hospital
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MATSUURA Satoko
Department of Pharmacology, Gifu Pharmaceutical University
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Takaoka Yuko
Department Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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