HISTAMINE RELEASE FROM RAT NEUTROPHILS AND MAST CELLS AS INDUCED BY IONOPHORE —A PHARMACOLOGICAL APPROACH—
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概要
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A comparative study was carried out on the histamine release from rat neutrophils and mast cells by calcium ionophore A 23 187 (Ionophore). A maximum release of histamine from neutrophils was induced by 10<SUP>-6</SUP> g/ml Ionophore and that from mast cells was 5×10<SUP>-6</SUP> g/ml. A fairly good correlation was found between the <SUP>45</SUP>Ca incorporation into and the histamine release from both cells . The Ionophore-induced histamine release from both cells was decreased in Ca<SUP>2+</SUP>-free Tyrodes solution and by pretreatment with 0.05 M EDTA. Effects of different drugs on Ionophore-induced histamine release from neutrophils were similar to those seen in mast cells. Dibutyl cyclic adenosine monophosphate, theophylline, isoproterenol and prostaglandin E<SUB>1</SUB> had no or only a slight inhibition on the release. The dose dependent inhibition of release was observed with disodium cromoglycate, N-(3, 4-dimethoxycinnamoyl) anthranilic acid and disodium baicalein phosphate, in experiments using both cells. Colchicine did not inhibit the reaction in these cells, however phosphatidylserine enhanced the reaction. On the other hand, the effect of concanavalin A was different in each type of cells, the release from mast cells was inhibited while the release from neutrophils was potentiated. These findings suggest the similarity of biochemical events in Ionophore-induced histamine release from neutrophils and mast cells.
- 社団法人 日本薬理学会の論文
著者
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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