The effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice.
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概要
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Effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice was studied. Employed models are nephrotoxic serum (NTS) nephritis in ddY or A/He mice, rabbit IgG (RGG) accelerated NTS nephritis in ddY mice and spontaneous nephritis in (NZB × NZW) F<SUB>1</SUB> mice. The severity of nephritis was evaluated by measuring proteinuria and serological parameters and examining renal tissue by light microscopy. Therapy with FUT-175 clearly prevented the pathological changes of proteinuria and serological parameters in all four nephritis models. By contrast, treatment hardly affected histopathological changes of the kidney in any of the models. Cyclophosphamide used as a comparative drug showed more clearly remission of the onset and development of NTS nephritis and RGG accelerated NTS nephritis in ddY mice by means of the changes of urinary and selorogical parameters. These evidences suggest that FUT-175 shows beneficial effects on the nephritis in either normal or complement deficient mice.
- 公益社団法人 日本薬理学会の論文
著者
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MATSUURA NAOSUKE
Department of Pharmacology, Gifu College of Pharmacy
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Yamada Hiroaki
Department Of Chemistry Faculty Of Science Chiba Univeristy
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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SHIMAZAWA Tsukasa
International Academy of Paramedical Technology
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INAGAKI Naoki
Department of Pharmacology, Gifu College of Pharmacy
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