Liver injury model in mice for immunopharmacological study.
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概要
- 論文の詳細を見る
Experimental liver injury was produced in mice by the immunological technique. The utility of these models as an immunopharmacological method was investigated. The first model was produced by the injection of anti-basic liver protein (BLP) rabbit antibody into DBA/2 mice that had been previously immunized with rabbit IgG. The second liver injury was caused by injection of anti-liver specific protein (LSP) rabbit antibody into DBA/2 mice. The third model was produced by the injection of bacterial lipopolysaccharide (LPS) into <I>Corynebacterium parvum</I> pretreated ddY mice. In all injury models, extensive liver parenchymal cell damage was estimated by elevation of glutamate transaminase (GOT and GPT) activity. These were confirmed by histopathological studies of the liver. Typical histopathological changes in the liver from injured mice were submassive hepatocellular necrosis and infiltration of granulocytes and lymphocytes into the portal tract and sinusoid in the necrotic lesion. Administration of prednisolone and cyclophosphamide for 10 days prior to injection of eliciting antibodies or LPS suppressed the elevation of serum transaminase levels in all experimental liver injury models. Cianidanol and sylibin inhibited the elevation of GOT and GPT in anti-BLP induced liver injured mice. These evidences suggest that the above models are suitable for investigating the remedy for liver diseases.
- 公益社団法人 日本薬理学会の論文
著者
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Yakuo Ikuhisa
Department Of Pharmacology Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Kasahara Masao
Department Of Electronics And Information Science Faculty Of Engineering And Design Kyoto Institute
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Yamada Hiroaki
Department Of Chemistry Faculty Of Science Chiba Univeristy
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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SHIMAZAWA Tsukasa
Department of Pharmacology, Gifu Pharmaceutical University
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NIU Kazumi
Division of Pharmacology, Sanwa Chemical Institute
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ASANO Kyouichi
Division of Pharmacology, Sanwa Chemical Institute
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SHIMIZU Tamotsu
Division of Pharmacology, Sanwa Chemical Institute
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