Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.
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概要
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Effects of hydrocortisone, prednisolone and dexamethasone on IgE antibody-mediated homologous passive cutaneous anaphylaxis (PCA) and mediator-induced skin reactions were investigated. PCA and skin reactions were evoked at the same time in the dorsal skin of a rat. Administrations of glucocorticoids inhibited not only the PCA but also the skin reactions caused by histamine, serotonin and leukotriene (LT) C<SUB>4</SUB> significantly. It is suggested, therefore, that glucocorticoids inhibit the increase of vascular permeability non-specifically. This action of glucocorticoids might contribute at least in part to its inhibitory effect on the PCA.
- 公益社団法人 日本薬理学会の論文
著者
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Miura Toru
Department Of Biology Graduate School Of Arts And Sciences University Of Tokyo
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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MIURA Toru
Department of Pharmacology, Gifu Pharmaceutical University
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