A COMPARATIVE STUDY OF THE ANTI-ALLERGIC EFFECTS OF DISODIUM BAICALEIN 6-PHOSPHATE (BPS) AND DISODIUM CROMOGLYCATE (DSCG)
スポンサーリンク
概要
- 論文の詳細を見る
A comparative study was carried out on the effects of a soluble derivative of baicalein, disodium baicalein 6-phosphate (BPS) and disodium cromoglycate (DSCG) on the immediate type allergic reactions. BPS not only inhibited reaginic antibodymediated reactions including antigen-induced mediator release from monkey lung, homologous PCA in rats, and reaginic antibody-mediated degranulation of mast cell, but also non-reaginic antibody-mediated reactions such as mediator release from guinea pig lung sensitized with ovalbumin and that from human lung caused by antiIgE. The agent, however, did not affect the mediator release from lung of rats sensitized with dinitrophynylated ascaris extract plus <I>Bordetella pertussis</I>. On the other hand, DSCG showed characteristic properties as an inhibitor of reaginic antibody-mediated reaction. It is thus assumed that the functional site of reaginic antibody is well fixed with DSCG at a definite distance between the two-chromone-nuclei while that of IgG is readily fixed with the two molecules of baicalein or BPS.
- 社団法人 日本薬理学会の論文
著者
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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YANAGIHARA Yukiyoshi
Department of Pharmacology, Gifu College of Pharmacy
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Sakamoto Kenichi
Department Of Anesthesia Ehime Rousai Hospital
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WATANABE Shigekatsu
Department of Pharmacology, Gifu College of Pharmacy
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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SAKAMOTO Kenichi
Department of Pharmacology, Gifu College of Pharmacy
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