Synthesis of Trimethylhydroquinone Derivatives as Anti-allergic Agents with Anti-oxidative Actions
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概要
- 論文の詳細を見る
A novel series of trimethylhydroquinone derivatives was synthesized and evaluated for their anti-lipid peroxidation activity in rat liver microsomes, inhibition of rat basophilic leukemia-1 (RBL-1) cell 5-lipoxygenase and 48h homologous passive cutaneous anaphylaxis (PCA) activity in rats. 4-[4-[4-(Diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (9c) exhibited the ability to inhibit Fe^<3+>-ADP induced NADPH dependent lipid peroxidation (IC_<50>=5.3×10^<-7>M), 5-lipoxygenase ((IC_<50>=3.5×10^<-7>M) and PCA reaction (57% inhibition at 100 mg/kg p.o.).
- 公益社団法人日本薬学会の論文
- 1999-02-15
著者
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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SATOH Toshio
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Satoh T
Yakuhan Pharmaceutical Co. Ltd. Hokkaido Jpn
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Nakano H
Department Of Physics And Astronomy And Center For Gravitational Wave Astronomy The University Of Te
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Nakano H
Lithography Tech. Dept. Sony Corporation Msnc
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Satoh Toshio
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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KAWASAKI Nobuhide
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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MIYATAKA Hideki
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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NISHIKI Mayumi
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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NAKANO Hiroyuki
Theoretical Astrophysics, California Institute of Technology Pasadena
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MATSUMOTO Hitoshi
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Nishiki Mayumi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Satoh Toshio
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Miyataka Hideki
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Satoh Toshio
Faculty Of Pharmaceutical Science Tokushima Bunri University
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Matsumoto Hitoshi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Matsumoto Hitoshi
School Of Pharmacy Tokushima University Of Arts And Science
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Miyataka Hideki
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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NAKANO Hiroyuki
Department of Physics and Astronomy, and Center for Gravitational Wave Astronomy, The University of Texas at Brownsville
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NAKANO Hiroyuki
Department of Earth and Space Science, Graduate School of Science Osaka University
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