A Kampo Formulation : Byakko-ka-ninjin-to(Bai-Hu-Jia-Ren-Sheng-Tang)Inhibits IgE-Mediated Triphasic Skin Reaction in Mice : The Role of Its Constituents in Expression of the Efficacy

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概要

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• We have demonstrated that oraladministration of a Kampo formulation, Byakko-ka-ninjin-to(Bai-Hu-Jia-Ren-Sheng-Tang), inhibited IgE-mediated triphasic skin reaction, including immediate phase response(IPR), late phase response(LPR)and very late phase response(vLPR), in passively sensitized mice with anti-DNP IgE antibody. Variant formulations of Byakko-ka-ninjin-to withour Gypsum Fibrosum(Sekko), Glycyrrhizae Radix(Kanzo)or Oryzae Semen(Kobei)attenuated the inhibitory effect as compated with that of Byakko-ka-ninjin-to. The decreased effect of Byakko-ka-ninjin-to without Kanzo was restored by the addition of Kanzo to the variant formulations before oral administration, while the decreased effect of Byakko-ka-ninjin-to without Sekko could not be recocered by the addition of Sekko. Comparison of HPLC profiles of variant formulations without one crude drug with that of original Byakko-ka-ninjin-to recealed that some peaks could be detected only when five constituent crude drugs were simultaneously present during the preparation of Byakko-ka-ninjin-to formulation. Since elimination of Sekko from the Byakko-ka-ninjin-to constituents attenuated the efficacy although it did not show any activity per se, mutual interaction of Sekko with other constituents during the preparation may result in the production of new components. These findings suggest that the effect of Byakko-ka-ninjin-to formulation on cutaneous inflammatory disease can differ from the sum of the effect of the individual constituents.

• 社団法人日本薬学会の論文
• 2001-03-01

著者

• NAGAI Hiroichi

  Department of Pharmacology, Gifu Pharmaceutical University

• SAIKI Ikuo

  Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti

• Saiki Ikuo

  富山大学 薬学研究科応用薬理学

• Saiki I

  Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama

• TATSUMI Takeshi

  Department of Pathogenic Biochemistry, Institute of Natural Medicine

• YAMADA Tomohiro

  Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti

• NUNOME Shinyu

  Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.

• TERASAWA Katsutoshi

  Institute of Natural Medicine, Department of Japanese Oriental(Kampo)Medicine, Faculty of Medicine,

• TANI Tadato

  Department of Pharmacognosy

• SAIKI Ikuo

  Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama

• Terasawa Katsutoshi

  群馬大学 医学部医学科統合和漢診療学講座

• Tatsumi Takeshi

  Department Of Pathogenic Biochemistry Institute Of Natural Medicine:department Of Japanese Oriental

• Tatsumi Takeshi

  富山医科薬科大学 和漢診療

• Nunome Shinyu

  富山医科薬科大学和漢薬研究所

• Nunome Shinyu

  Kampo And Pharmacognosy Laboratory Tsumura & Co.

• Saiki Ikuo

  Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama

• Terasawa K

  Dept. Of Japanese Oriental Medicine Graduate School Of Medicine Chiba University

• Nagai Hiroichi

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Saiki Ikuo

  Department Of Pathological Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceuti

• Saiki Ikuo

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Tatsumi Takeshi

  Department Of Chemistry Faculty Of Science Kyoto University

• Nagai Hiroichi

  Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University

• Nagai Hiroichi

  Department Of Clinical Pharmacology Gifu Pharmaceutical University

• Yamada Tomohiro

  Department Of Clinical Pathology Kinki University School Of Medicine

• Saiki Ikuo

  Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica

• Tani Tadato

  Department Of Kampo Pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un

• Saiki Ikuo

  Department Of Bioscience Institute Of Natural Medicine Toyama University

• Nagai Hiroichi

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama

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