Inhibitory Effects of Caffeic Acid Phenethyl Ester Analogues on Experimental Lung Metastasis of Murine Colon 26-L5 Carcinoma Cells
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概要
- 論文の詳細を見る
We have previously examined the antiproliferative activity of caffeic acid phenethyl ester (CAPE) and its 20 analogues against six tumor cell lines, and found that CAPE analogues possess selective antiproliferative activity toward the murine colon 26-L5 carcinoma cell line. To extend our study, the effects of CAPE analogues on the metastatic development of murine colon 26-L5 carcinoma cells in the lung were examined. The oral administration of CAPE (5 mg/mice/d) for 7d after tumor inoculation decreased the tumor weight and the number of tumor nodules in the lung by 50% and 50%, respectively, compared to the control, while CAPE (5 mg/mice/d) administered for 7d before tumor inoculation showed no significant effect. Besides CAPE, 4-phcnylbutyl caffeate, 8-phenyl-7-octenyl caffeate, 2-cytlohexylethyl caffeate and n-octyl caffeate at an oral dose of 2 mg/mice/d caused a 55%, 43%, 55% and 35% reduction of the tumor nodules in their lung metastasis formation, respectively. These results further elaborate the possibility of CAPE and its analogues to become a new class of chemopreventive agents for the treatment of colon cancer metastasis.
- 公益社団法人日本薬学会の論文
- 2003-05-01
著者
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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門田 重利
富山医科薬科大学和漢薬研究所化学応用部門
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SAIKI Ikuo
Institute of Natural Medicine, University of Toyama
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BANSKOTA Arjun
Institute of Natural Medicine, University of Toyama
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Banskota A
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
富山医科薬科大学和漢薬研究所
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Banskota Arjun
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Saiki Ikuo
富山大学 薬学研究科応用薬理学
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Saiki I
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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HARIMAYA Yuko
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Kadota Shigetoshi
富山大学和漢医薬学総合研究所 化学応用分野
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Kadota Shigetoshi
インドネシア
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Saiki Ikuo
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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Saiki I
Institute Of Natural Medicine University Of Toyama
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
富山医科薬科大学 生薬
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagaoka Takema
富山医科薬科大学和漢薬研究所
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Saiki Ikuo
Department Of Pathogenic Biochemistry Research Institute For Wakan-yaku (traditional Sino-japanese M
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Saiki Ikuo
Department Of Pathological Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceuti
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Banskota A
富山医科薬科大学和漢薬研究所化学応用部門
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Banskota Arjun
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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門田 重利
Institute Of Natural Medicine University Of Toyama
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Saiki Ikuo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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KOIZUMI Keiichi
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kalauni S
Institute Of Natural Medicine University Of Toyama
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Kadota S
Toyama Medical And Pharamaceutical Univ. Toyama Jpn
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Harimaya Yuko
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Koizumi Keiichi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Banskota Arjun
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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Saiki Ikuo
Institute Of Immunological Science Hokkaido University
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
Institute For Marine Biosciences National Research Council
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門田 重利
Institute of Natural Medicine, University of Toyama
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