Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants(Pharmacognosy)

概要

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Among 288 extracts, prepared from 96 medicinal plants used in Vietnamese traditional medicine to treat gout and related symptoms, 188 demonstrated xanthine oxidase (XO) inhibitory activity at 100μg/ml, with 46 having greater than 50% inhibition. At 50μg/ml, 168 of the extracts were active, with 21 possessing more than 50% inhibition. At 25 μg/ml, 146 extracts exhibited inhibitory activity, with 8 showing over 50% inhibition, while 126 extracts presented activity at 10μg/ml, with 2 having greater than 50% inhibition. The MeOH extracts of Artemisia vulgaris, Caesalpinia sappan (collected at the Seven-Mountain area), Blumea balsamifera (collected in Lam Dong province), Chrysanthemum sinense and MeOH-H_2O extract of Tetracera scandens (Khanh Hoa province) exhibited strong XO inhibitory activity with IC_<50> values less than 20 μg/ml. The most active extract was the MeOH extract of the flower of C. sinense with an IC_<50> value of 5.1 μg/ml. Activity-guided fractionation of the MeOH extract led to the isolation of caffeic acid (1), luteolin (2), eriodictyol (3), and 1, 5-di-O-caffeoylquinic acid (4). All these compounds showed significant XO inhibitory activity in a concentration-dependent manner, and the activity of 2 was more potent (IC_<50> 1.3 μM) than the clinically used drug, allopurinol (IC_<50> 2.5 μM).
社団法人日本薬学会の論文
2004-09-01